TCS JNK 5a | JNK Inhibitor IX | Apoptosis Inducer | AmBeed-信号通路专用抑制剂

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TCS JNK 5a 99%+

货号：A222483 同义名： JNK Inhibitor IX;c-Jun N-terminal Kinase Inhibitor IX

TCS JNK 5a是JNK3的有效抑制剂，其pIC50为6.7。它还抑制JNK2，其pIC50为6.5。

TCS JNK 5a 化学结构
CAS号：312917-14-9

TCS JNK 5a 3D分子结构
CAS号：312917-14-9

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TCS JNK 5a 纯度/质量文件产品仅供科研

货号：A222483 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

JNK 亚型比较

产品名称	JNK ↓ ↑	JNK1 ↓ ↑	JNK2 ↓ ↑	JNK3 ↓ ↑	其他靶点	纯度
Mulberroside A	✔					99%+
Loureirin B	✔				Calcium Channel,Potassium Channel	99%+
Ginsenoside Re	✔				NF-κB	98%
(+)-(3R,8S)-Falcarindiol	✔				ERK,STAT	99%+
trans-Zeatin	✔				ERK,p38 MAPK	95+%
Urolithin B	✔				ERK,NF-κB	99%+
Cucurbitacin IIb	✔				NF-κB	99%+
Astragaloside IV	✔				NF-κB,mTOR,Akt	98%
NDMC101	✔					99%+
DB07268		++++ JNK1, IC50: 9 nM				99%+
SP600125	+ MKK4, IC50: 0.4 μM	+++ JNK1, IC50: 40 nM	+++ JNK2, IC50: 40 nM	+++ JNK3, IC50: 90 nM		98%
JNK-IN-7		++++ JNK1, IC50: 1.5 nM	++++ JNK2, IC50: 2 nM	++++ JNK3, IC50: 0.7 nM		99%+
JNK-IN-8		++++ JNK1, IC50: 4.7 nM	+++ JNK2, IC50: 18.7 nM	++++ JNK3, IC50: 1 nM		99%+
3,3',5-Triiodo-L-thyronine		++ JNK1, Kd: 240 nM	++ JNK2, Kd: 290 nM	+++ JNK3, Kd: 66 nM		99%+
IQ-1S free acid		+ JNK1, IC50: 390 nM	++ JNK2, IC50: 360 nM	+++ JNK3, IC50: 87 nM		98%
BI-78D3	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM		99%+
Bentamapimod		+++ JNK1, IC50: 80 nM	+++ JNK2, IC50: 90 nM	++ JNK3, IC50: 230 nM		99%+
Resveratrol		+ JNK1, IC50: 50 μM				98%
Indirubin-3′-oxime		✔				99%+
SU3327	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM		99%+
JNK Inhibitor VIII		++++ JNK1, Ki: 2 nM JNK1, IC50: 45 nM	++++ JNK2, Ki: 4 nM JNK2, IC50: 160 nM	+++ JNK3, Ki: 52 nM		99%+
Doramapimod			✔			99%+
RPI-1			✔			99%+
TCS JNK 5a			++ JNK2, pIC50: 6.5	++ JNK3, pIC50: 6.7		99%+
SP 600125, negative control			+ JNK2, IC50: 18 μM	+ JNK3, IC50: 24 μM		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

TCS JNK 5a 生物活性

靶点	JNK2 JNK2, pIC50:6.5 JNK3 JNK3, pIC50:6.7
描述	c-Jun N-terminal kinase (JNK) is implicated in various human diseases, including cancer, inflammatory disorders, and neurodegeneration. JNK inhibitor IX is a potent JNK inhibitor with pIC50 values of 6.5 and 6.7 for JNK2 and JNK3, respectively^[3]. Pre-treatment of human dermal fibroblasts with JNK inhibitor IX (10μM) 30min before chromium exposure significantly reduces caspase-3 activity compared to the group only treated with chromium^[4]. Treatment of myeloid cells with JNK inhibitor IX (10μM) for 24 h significantly reduced JNK phosphorylation and increased apoptotic cell death in response to imatinib mesylate^[5].
作用机制	JNK inhibitor IX is a potent, ATP-competitive inhibitor of both JNK2 and JNK3^[3].

TCS JNK 5a 参考文献

[1]Rudolf E, Cervinka M. Trivalent chromium activates Rac-1 and Src and induces switch in the cell death mode in human dermal fibroblasts. Toxicol Lett. 2009 Aug 10;188(3):236-42.

[2]Angell RM, Atkinson FL, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.

[3]Angell RM, Atkinson FL, Brown MJ, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007;17(5):1296-1301. doi:10.1016/j.bmcl.2006.12.003

[4]Rudolf E, Cervinka M. Trivalent chromium activates Rac-1 and Src and induces switch in the cell death mode in human dermal fibroblasts. Toxicol Lett. 2009;188(3):236-242. doi:10.1016/j.toxlet.2009.04.019

[5]Mancini M, Veljkovic N, Corradi V, et al. 14-3-3 ligand prevents nuclear import of c-ABL protein in chronic myeloid leukemia. Traffic. 2009;10(6):637-647. doi:10.1111/j.1600-0854.2009.00897.x

TCS JNK 5a 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.01mL

0.60mL

0.30mL

15.04mL

3.01mL

1.50mL

30.08mL

6.02mL

3.01mL

TCS JNK 5a 技术信息

CAS号	312917-14-9
分子式	C₂₀H₁₆N₂OS
分子量	332.419

别名	JNK Inhibitor IX;c-Jun N-terminal Kinase Inhibitor IX;TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671, SC 202671, SC202671
运输	蓝冰

存储条件

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 18 mg/mL(54.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

TCS JNK 5a 99%+

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TCS JNK 5a 99%+

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全球学术期刊中引用的产品

TCS JNK 5a 质控信息

TCS JNK 5a 生物活性

TCS JNK 5a 参考文献

TCS JNK 5a 实验方案

TCS JNK 5a 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

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TCS JNK 5a 纯度/质量文件产品仅供科研