Pirenzepine 2HCl | Gastrozepin dihydrochloride | M1 mAChR Antagonist

首页 / / / / Pirenzepine 2HCl

盐酸哌仑西平 /Pirenzepine 2HCl {[allProObj[0].p_purity_real_show]}

货号：A119911 同义名： Gastrozepin dihydrochloride;Pirenzepin dihydrochloride

Pirenzepine 2HCl is a is an anticholinergic agent and induces the dimerization of muscarinic M1 receptors, used to treat myopia, gastric and duodenal ulcers.

Pirenzepine 2HCl 化学结构
CAS号：29868-97-1

Pirenzepine 2HCl 3D分子结构
CAS号：29868-97-1

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

Pirenzepine 2HCl 纯度/质量文件产品仅供科研

货号：A119911 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell Host Microbe, 2024. Ambeed. [ A163338 ]; • Cancer Res., 2024. Ambeed. [ A295334 ]; • J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]; • J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]; • JBC, 2024, 107935. Ambeed. [ A194396 ]; 更多 >

AChR 亚型比较

产品名称	AChE ↓ ↑	AChR ↓ ↑	mAChR ↓ ↑	nAChR ↓ ↑	其他靶点	纯度
Donepezil	+++ hAChE, IC50: 11.6 nM bAChE, IC50: 8.12 nM					98%
Loganin	++ AChE, IC50: 3.95 μM					99%+
topride HCl	++ AChE, IC50: 2.04 μM					98%
Dehydroevodiamine HCl	✔					99%+
Jatrorrhizine	++ AChE, IC50: 872 nM					99%+
Palmatine	++ AChE, IC50: 0.51 μM					98%
(-)-Huperzine A	++++ AChE (G4 form), Ki: 7 nM					98%
Galanthamine HBr	++ AChE, IC50: 0.35 μM					98%
Trospium chloride		✔				99%
Tiotropium Bromide Monohydrate		✔				98+%
Gallamine Triethiodide		+ AChR, IC50: 68.0 μM				98%
Hexamethonium Bromide		✔				99%
Pancuronium dibromide		✔				98%
Neostigmine bromide		✔				98%
Orphenadrine citrate		✔				98%
Oxybutynin		✔				98%
Irsogladine		✔			PDE	98%
Pyridostigmine bromide		✔				99+%
Rivastigmine		+ AChR, IC50: 5.5 μM				98%
Paroxetine hydrochloride		✔				97%
Rocuronium Bromide		✔				98%
Tropicamide			+++ M4 mAChR, IC50: 8 nM			98%
Diphenmanil methylsulfate			✔			98%
Umeclidinium bromide			✔			95%
Otilonium bromide			✔			98%
Flavoxate HCl			+ mAChR, IC50: 12.2 μM			98%
Ipratropium bromide			✔			98%
Diphenidol HCl			✔			98%
Darifenacin hydrobromide			++++ M3 mAChR, pKi: 8.9			98%
Aclidinium Bromide			++++ M4 mAChR, Ki: 0.21 nM M2 mAChR, Ki: 0.1 nM			98%
Oxybutynin chloride			✔			99%
Pentoxyverine citrate			✔			98%
Solifenacin			✔			98%
Catharanthine				✔		98%
Benzethonium chloride				+++ α7 nAChRs, IC50: 122 nM α4β2 nAChRs, IC50: 49 nM		99+%
Vinblastine sulfate				+ nAChR, IC50: 8.9 μM		99%
PNU-120596				++ α7 nAChR, EC50: 216 nM		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Pirenzepine 2HCl 生物活性

描述

Pirenzepine Dihydrochloride is a selective M1 muscarinic receptor antagonist. Pirenzepine (Dihydrochloride) has antisecretory properties on gastric acid and pepsin secretion. Significant cytoprotective properties of pirenzepine have been observed on a variety of experimentally induced peptic ulcerations^[3]. In vivo，Pirenzepine (5-25 mg/kg i.v.) also depressed indirect electrical stimulation-evoked twitches of the cat tibialis anterior and soleus muscle preparations^[4]. Pirenzepine was found to impair passive avoidance learning when given i.c.v. 20 min pre-training. The median latencies in pirenzepine-treated animals are 79.5, 11, 27 and 25.5 seconds with doses of 0.03, 0.1, 0.3 and 1 μg per mouse, respectively^[5].

Pirenzepine 2HCl 参考文献

[1]Daeffler L, Schmidlin F, et al. Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors. Br J Pharmacol. 1999 Mar;126(5):1246-52.

[2]Eglen RM, Hegde SS, Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev. 1996 Dec;48(4):531-65.

[3]Del Tacca M, Danesi R, Blandizzi C, Bernardini MC. Un antimuscarinico selettivo: la pirenzepina. Rassegna delle sue proprietà farmacologiche e cliniche [A selective antimuscarinic agent: pirenzepine. Review of its pharmacologic and clinical properties]. Minerva Dietol Gastroenterol. 1989 Jul-Sep;35(3):175-89. Italian. PMID: 2574837.

[4]Ojewole JA. Effects of pirenzepine (Gastrozepin) on skeletal muscle contractility. Methods Find Exp Clin Pharmacol. 1983 Nov;5(9):619-23. PMID: 6689440.

[5]Caulfield MP, Higgins GA, Straughan DW. Central administration of the muscarinic receptor subtype-selective antagonist pirenzepine selectively impairs passive avoidance learning in the mouse. J Pharm Pharmacol. 1983 Feb;35(2):131-2. doi: 10.1111/j.2042-7158.1983.tb04290.x. PMID: 6131987.

Pirenzepine 2HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.57mL

4.71mL

2.36mL

Pirenzepine 2HCl 技术信息

CAS号	29868-97-1
分子式	C₁₉H₂₃Cl₂N₅O₂
分子量	424.324

别名	Gastrozepin dihydrochloride;Pirenzepin dihydrochloride;Gastrozepin;Pirenzepine (hydrochloride);LS 519;Pirenzepine dihydrochloride
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 25 mg/mL(58.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 75 mg/mL(176.75 mM)，配合低频超声助溶

动物实验配方

盐酸哌仑西平 /Pirenzepine 2HCl {[allProObj[0].p_purity_real_show]}

Pirenzepine 2HCl 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Pirenzepine 2HCl 质控信息

Pirenzepine 2HCl 生物活性

Pirenzepine 2HCl 参考文献

Pirenzepine 2HCl 实验方案

Pirenzepine 2HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

盐酸哌仑西平 /Pirenzepine 2HCl {[allProObj[0].p_purity_real_show]}

Pirenzepine 2HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Pirenzepine 2HCl 质控信息

Pirenzepine 2HCl 生物活性

Pirenzepine 2HCl 参考文献

Pirenzepine 2HCl 实验方案

Pirenzepine 2HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Pirenzepine 2HCl 纯度/质量文件产品仅供科研