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Pancuronium dibromide

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Chemical Structure| 15500-66-0 同义名 : Pavulon
CAS号 : 15500-66-0
货号 : A737050
分子式 : C35H60Br2N2O4
纯度 : 98%
分子量 : 732.67
MDL号 : MFCD00079223
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(143.31 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(136.49 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • AChR
描述 Pancuronium Dibromide is a competitive AChR antagonist.Pancuronium (10 mg/kg ) reduced ACh-induced bronchoconstriction. At doses which produce 100% neuromuscular blockade, both pancuronium (0.04 mg/kg) and gallamine (4 mg/kg) potentiated vagally-induced bronchoconstriction[3].Competitive block of embryonic-type nicotinic acetylcholine receptor channels by pancuronium or atracurium after preincubation of outside-out patches with the respective blocker[4]. Moreover, Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.36mL

0.27mL

0.14mL

6.82mL

1.36mL

0.68mL

13.65mL

2.73mL

1.36mL
参考文献

[1]Lowenick CV, Krampfl K, et al. Open channel and competitive block of nicotinic receptors by pancuronium and atracurium. Eur J Pharmacol. 2001 Feb 9;413(1):31-5.

[2]Melnikov AL, Malakhov KY, et al. Cardiac effects of non-depolarizing neuromuscular blocking agents pancuronium,vecuronium, and rocuronium in isolated rat atria. Gen Pharmacol. 1999 Oct;33(4):313-7.

[3]Fryer AD, Maclagan J. Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335(4):367-71.

[4]Löwenick CV, Krampfl K, Schneck H, Kochs E, Bufler J. Open channel and competitive block of nicotinic receptors by pancuronium and atracurium. Eur J Pharmacol. 2001 Feb 9;413(1):31-5.

[5]Maestrone E, Magnelli V, Nobile M, Usai C. Extracellular pancuronium affects sodium current in chick embryo sensory neurones. Br J Pharmacol. 1994 Jan;111(1):283-7.