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欧诗美锭 /Oxatomide {[allProObj[0].p_purity_real_show]}

货号：A357468 Ambeed 开学季，买赠积分，赢豪礼

Oxatomide is a first-generation antihistamine of the diphenylmethylpiperazine (benzhydrylpiperazine) class.

Oxatomide 化学结构 CAS号：60607-34-3
Oxatomide 化学结构
CAS号：60607-34-3
Oxatomide 3D分子结构
CAS号：60607-34-3
Oxatomide 化学结构 CAS号：60607-34-3
Oxatomide 3D分子结构 CAS号：60607-34-3
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Oxatomide 纯度/质量文件 产品仅供科研

货号：A357468 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 5-HT ↓ 5-HT1 ↓ 5-HT2 ↓ 5-HT3 ↓ 5-HT5 ↓ 5-HT6 ↓ 5-HT7 ↓ 其他靶点 纯度
Desvenlafaxine ++

5-HT, Ki: 40.2 nM

 		{[allProObj[0].p_purity_real_show]}
Lamotrigine +

5-HT (rat brain synaptosomes), IC50: 474 μM

5-HT (human platelets), IC50: 240 μM

 		{[allProObj[0].p_purity_real_show]}
Venlafaxine ✔ {[allProObj[0].p_purity_real_show]}
Fluvoxamine maleate ✔ {[allProObj[0].p_purity_real_show]}
Iloperidone ✔ {[allProObj[0].p_purity_real_show]}
Ziprasidone HCl ✔ {[allProObj[0].p_purity_real_show]}
Atomoxetine HCI +

5-HT, Ki: 77 nM

 		{[allProObj[0].p_purity_real_show]}
Dapoxetine HCl ✔ {[allProObj[0].p_purity_real_show]}
Trazodone ✔ {[allProObj[0].p_purity_real_show]}
Clomipramine HCl ✔ {[allProObj[0].p_purity_real_show]}
Mirtazapine ✔ {[allProObj[0].p_purity_real_show]}
Escitalopram oxalate +++

5-HT, Ki: 0.89 nM

 		{[allProObj[0].p_purity_real_show]}
Duloxetine ✔ {[allProObj[0].p_purity_real_show]}
Sertraline HCl ++

5-HT, Ki: 13 nM

 		{[allProObj[0].p_purity_real_show]}
Citalopram HBr +++

serotonin reuptake, IC50: 1.8 nM

 		{[allProObj[0].p_purity_real_show]}
Latrepirdine 2HCl ✔ GluR {[allProObj[0].p_purity_real_show]}
Fluoxetine HCl ✔ {[allProObj[0].p_purity_real_show]}
Paroxetine hydrochloride ✔ AChR {[allProObj[0].p_purity_real_show]}
BMY 7378 ++

5-HT1A, pIC50: 6.4

5-HT1D, pIC50: 5.9

 		+

5-HT2, pIC50: 5.5

 		{[allProObj[0].p_purity_real_show]}
Flibanserin +++

5-HT1A, Ki: 1 nM

 		+

5-HT2A, Ki: 49 nM

 		{[allProObj[0].p_purity_real_show]}
LY310762 +

5-HT1D, Ki: 249 nM

 		{[allProObj[0].p_purity_real_show]}
Cyclobenzaprine HCI ✔ {[allProObj[0].p_purity_real_show]}
Blonanserin +++

5-HT2, Ki: 3.98 nM

 		{[allProObj[0].p_purity_real_show]}
Cyproheptadine HCl ++++

5-HT2, IC50: 0.6 nM

 		{[allProObj[0].p_purity_real_show]}
Olanzapine ✔ {[allProObj[0].p_purity_real_show]}
Pimavanserin hemitartrate +++

5-HT2A, pIC50: 8.7

 		{[allProObj[0].p_purity_real_show]}
Ketanserin +++

5-HT2C (Human), Ki: 2.5 nM

5-HT2C (Rat), Ki: 50 nM

 		{[allProObj[0].p_purity_real_show]}
Loxapine succinate ++

5-HT2 (bovine), Ki: 6.6 nM

5-HT2 (human), Ki: 6.8 nM

 		{[allProObj[0].p_purity_real_show]}
Agomelatine ✔ {[allProObj[0].p_purity_real_show]}
Clozapine ✔ {[allProObj[0].p_purity_real_show]}
Amitriptyline +

5-HT2, Ki: 235 nM

 		SERT {[allProObj[0].p_purity_real_show]}
PRX-08066 maleate +++

5-HT2B, IC50: 3.4 nM

 		{[allProObj[0].p_purity_real_show]}
RS-127445 ++++

5-HT2B, pIC50: 10.4

5-HT2B, pKi: 9.5

 		{[allProObj[0].p_purity_real_show]}
Sarpogrelate HCl ++++

5-HT2A, Kd: 2.1 nM

5-HT2C, Kd: 1.1 nM

 		{[allProObj[0].p_purity_real_show]}
Tropisetron ✔ {[allProObj[0].p_purity_real_show]}
Palonosetron ✔ {[allProObj[0].p_purity_real_show]}
Ramosetron HCl ++++

5-HT3 receptor, Ki: 0.091 nM

 		{[allProObj[0].p_purity_real_show]}
Ondansetron ✔ {[allProObj[0].p_purity_real_show]}
Granisetron ✔ {[allProObj[0].p_purity_real_show]}
Alosetron HCl ✔ {[allProObj[0].p_purity_real_show]}
Ondansetron hydrochloride dihydrate ✔ {[allProObj[0].p_purity_real_show]}
VUF10166 ++++

5-HT3AB, Ki: 22 nM

5-HT3A, Ki: 0.04 nM

 		{[allProObj[0].p_purity_real_show]}
Azasetron hydrochloride ++++

5-HT3, IC50: 0.33 nM

 		{[allProObj[0].p_purity_real_show]}
Asenapine maleate +++

5-HT1A, pKi: 8.6

5-HT1B, pKi: 8.4

 		++++

5-HT2C, pKi: 10.46

5-HT2A, pKi: 9.75

 		+++

5-HT5A, pKi: 8.84

 		++++

5-HT6, pKi: 9.6

 		++++

5-HT7, pKi: 9.94

 		{[allProObj[0].p_purity_real_show]}
Risperidone ++

5-HT1D, Ki: 84.6 nM

5-HT1B, Ki: 14.9 nM

 		++++

5-HT2C, Ki: 12 nM

5-HT2A, Ki: 61.9 nM

 		+

5-HT5A, Ki: 206 nM

 		++

5-HT7, Ki: 6.6 nM

 		{[allProObj[0].p_purity_real_show]}
SB 271046 HCl +++

5-HT6, pKi: 8.92

 		{[allProObj[0].p_purity_real_show]}
Intepirdine ++++

5-HT6, pKi: 9.63

 		{[allProObj[0].p_purity_real_show]}
SB-269970 HCl ++

5-HT7, pKi: 8.3

 		{[allProObj[0].p_purity_real_show]}
BRL 15572 ++

5-HT1D, pKi: 6

5-HT1B, pKi: 6.1

 		++

5-HT2B, pKi: 6.2

5-HT2A, pKi: 6.6

 		+

5-HT6, pKi: 5.9

 		+

5-HT7, pKi: 6.3

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl {[allProObj[0].p_purity_real_show]}
Cyclizine ✔ {[allProObj[0].p_purity_real_show]}
Loratadine +

B(0)AT2, IC50: 4 μM

 		{[allProObj[0].p_purity_real_show]}
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		{[allProObj[0].p_purity_real_show]}
Doxylamine succinate ✔ {[allProObj[0].p_purity_real_show]}
Ebastine ✔ {[allProObj[0].p_purity_real_show]}
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		{[allProObj[0].p_purity_real_show]}
Meclizine dihydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		{[allProObj[0].p_purity_real_show]}
Diphenhydramine HCl ✔ {[allProObj[0].p_purity_real_show]}
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		{[allProObj[0].p_purity_real_show]}
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		{[allProObj[0].p_purity_real_show]}
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		{[allProObj[0].p_purity_real_show]}
Pemirolast potassium ✔ {[allProObj[0].p_purity_real_show]}
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		{[allProObj[0].p_purity_real_show]}
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		{[allProObj[0].p_purity_real_show]}
Brompheniramine maleate ✔ {[allProObj[0].p_purity_real_show]}
Carbinoxamine maleate salt ✔ {[allProObj[0].p_purity_real_show]}
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		{[allProObj[0].p_purity_real_show]}
Ketotifen fumarate salt ✔ {[allProObj[0].p_purity_real_show]}
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR {[allProObj[0].p_purity_real_show]}
Famotidine ✔ {[allProObj[0].p_purity_real_show]}
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		{[allProObj[0].p_purity_real_show]}
Lafutidine ✔ {[allProObj[0].p_purity_real_show]}
Cimetidine ✔ {[allProObj[0].p_purity_real_show]}
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE {[allProObj[0].p_purity_real_show]}
Ranitidine ✔ {[allProObj[0].p_purity_real_show]}
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		{[allProObj[0].p_purity_real_show]}
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		{[allProObj[0].p_purity_real_show]}
S 38093 ++

rat H3 receptor, Ki: 1.44 μM

human H3 receptor, Ki: 1.2 μM

 		{[allProObj[0].p_purity_real_show]}
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		{[allProObj[0].p_purity_real_show]}
Azelastine HCl ✔ {[allProObj[0].p_purity_real_show]}
Epinastine HCl ✔ {[allProObj[0].p_purity_real_show]}
Levodropropizine ✔ {[allProObj[0].p_purity_real_show]}
Cyproheptadine hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Hesperetin ✔ {[allProObj[0].p_purity_real_show]}
Olopatadine HCl ✔ {[allProObj[0].p_purity_real_show]}
Mianserin hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Buclizine 2HCl ✔ {[allProObj[0].p_purity_real_show]}
Latrepirdine 2HCl ✔ GluR {[allProObj[0].p_purity_real_show]}
Cetirizine 2HCl ✔ {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Oxatomide 生物活性

描述 Oxatomide, a strong and orally effective antagonist of both H1-histamine and P2X7 receptors, exhibits antihistamine and anti-allergic properties. It nearly fully inhibits ATP-induced currents in human P2X7 receptors with an IC50 of 0.95 μM, blocks ATP-induced Ca2+ influx with an IC50 of 0.43 μM, and also suppresses serotonin[1][2].

Oxatomide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00033813 Muscular Dystrophy, Duchenne Phase 2 Completed - United States, District of Col... 展开 >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 收起 <<

Oxatomide 参考文献

[1]Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51.

[2]K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409.

Oxatomide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.34mL

0.47mL

0.23mL

11.72mL

2.34mL

1.17mL

23.44mL

4.69mL

2.34mL

Oxatomide 技术信息

CAS号60607-34-3
分子式C27H30N4O
分子量 426.553
别名
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 250 mg/mL(586.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Oxatomide | 60607-34-3 | Histamine Receptor | P2X Receptor | H1-histamine/P2X7 Receptor Antagonist | GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Membrane Transporter/Ion Channel | Histamine Receptor | P2X Receptor | 5-HT Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Oxatomide 纯度/质量文件 | Oxatomide 亚型比较 | Oxatomide 生物活性 | Oxatomide 临床数据 | Oxatomide 参考文献 | Oxatomide 实验方案 | Oxatomide 技术信息

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