产品说明书
Oxatomide
 |
同义名 : | - |
| CAS号 : | 60607-34-3 | |
| 货号 : | A357468 | |
| 分子式 : | C27H30N4O | |
| 纯度 : | 99%+ | |
| 分子量 : | 426.553 | |
| MDL号 : | MFCD00211147 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(586.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Oxatomide, a strong and orally effective antagonist of both H1-histamine and P2X7 receptors, exhibits antihistamine and anti-allergic properties. It nearly fully inhibits ATP-induced currents in human P2X7 receptors with an IC50 of 0.95 μM, blocks ATP-induced Ca2+ influx with an IC50 of 0.43 μM, and also suppresses serotonin[1][2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00033813 | Muscular Dystrophy, Duchenne | Phase 2 | Completed | - | United States, District of Col... 展开 >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.34mL 0.47mL 0.23mL |
11.72mL 2.34mL 1.17mL |
23.44mL 4.69mL 2.34mL |
| 参考文献 |
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