BAY-1797是一种高效、口服活性的选择性 P2X4 拮抗剂，对人 P2X4 的 IC50 为 211 nM。BAY-1797 在其他 P2X 离子通道上没有或表现出极弱的活性，具有抗伤害和抗炎作用。

AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth .

A 438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).

GW791343 2HCl is a P2X7 allosteric modulator exhibiting species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).

A-804598 是一个 CNS 渗透，竞争性和选择性的 P2X7 受体拮抗剂，作用于小鼠，大鼠和人的 P2X7 受体，IC50s 分别是 9 nM, 10 nM 和 11 nM。

AF-353 is a potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.

Gefapixant 是一种口服活性的 P2X3 受体（P2X3R）拮抗剂，对重组人 hP2X3 和 hP2X2/3 的 IC50 值分别约为 30 nM 和 100-250 nM。Gefapixant 可用于慢性咳嗽和膝骨关节炎的研究。

A-839977 is a selective P2X7 antagonist and blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively).

A 438079 is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).

BX430 is selective P2X4 allosteric antagonist with IC50 of 0.54 μM.

RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist.

JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively).

CTP Disodium Dihydrate is a P2X4 purinergic receptor agonist.

Oxatomide is a first-generation antihistamine of the diphenylmethylpiperazine (benzhydrylpiperazine) class.

KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM..

Gardenoside, a natural product isolated and purified from the fruits of Gardenia jasminoides Ellis, has anti-inflammatory, analgesic activities.

Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.