N106
货号：A1231634
N106 是一种新型肌质网钙 ATP 酶 (SERCA2a) SUMO ylation激活剂。N106 直接激活 SUMO -激活酶 E1 连接酶。
N106 化学结构 N106 3D分子结构 规格 价格 库存 数量
50μL*10mM(DMSO)
￥129随货￥99 咨询
100μL*10mM(DMSO)
￥209随货￥149 咨询
250μL*10mM(DMSO)
￥419 咨询
500μL*10mM(DMSO)
￥699 咨询
10mM*1mL(DMSO)
￥1001 咨询
1mg
￥346 咨询
5mg
￥819 咨询
10mg
￥1386 咨询
25mg
￥3024 咨询
50mg
￥5166 咨询
全球学术期刊中引用的产品
• Nature Communications , 2025, 16, 1871. Ambeed. A508148
]
• Biomaterials , 2025, 319, 123190. Ambeed. • Cell. Mol. Life Sci. , 2025, 82, 91. Ambeed. A154425
]
• Cellular Signalling , 2025, 130, 111680. Ambeed. A175370
]
• Structure , 2025. Ambeed. 更多 > N106 质控信息
CDC25B-IN-2
✔
Akt 99%+ Clevidipine
✔
97% Verapamil HCl
✔
99% Amlodipine
✔
99% Amlodipine maleate
✔
98% (+)-cis-Diltiazem HCl
✔
99% Zegocractin
++
Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM
99%+ Tanshinone IIA sulfonate sodium
✔
98% Ulixacaltamide
++
hCaV3.2, IC50: 110 nM
hCaV3.1, IC50: 50 nM
99%+ Dronedarone Hydrochloride
✔
95% Nitrendipine
+
Calcium channel, IC50: 95 nM
98% Efonidipine HCl monoethanolate
✔
98% Cinnarizine
✔
98% SEA0400
++
ROS,ERK,p38 MAPK 99%+ Fasudil HCl
✔
Rho,PKA 98% ML-9
✔
MLCK,Akt 99%+ Flunarizine 2HCl
+
Calcium channel, Ki: 68 nM
95% Lomerizine 2HCl
✔
98% Efonidipine
✔
98% Levamlodipine
✔
98% Nisoldipine
++
L-type Cav1.2, IC50: 10 nM
97% Isradipine
✔
98% Lacidipine
✔
98% Lercanidipine
✔
99% Loureirin B
✔
Potassium Channel 99%+ Tetracaine HCl
✔
98% Manidipine
+++
Calcium channel, IC50: 2.6 nM
99% Manidipine Dihydrochlorid
+++
Calcium channel, IC50: 2.6 nM
98% Nicardipine
✔
99% Wilforgine
✔
98+% Econazole
✔
99%+ Ginsenoside Rd
✔
NF-κB 98% Fendiline HCl
✔
98+% Mesaconitine
✔
98% Tetrandrine
✔
95% Nifedipine
✔
95% Nilvadipine
++++
Calcium channel, IC50: 0.03 nM
98% Barnidipine
++++
[3 H]nitrendipine, Ki: 0.21 nM
95+% Azelnidipine
✔
97% Levetiracetam
✔
98% Nimodipine
✔
95% Benidipine HCl
✔
98% Pinaverium bromide
✔
98% Pranidipine
✔
99% NP118809
+
L-type calcium channel, IC50: 12.2 μM
N-type Ca2+ channel, IC50: 0.11 μM
98% Amlodipine Besylate
+++
Calcium channel, IC50: 1.9 nM
97% Cilnidipine
✔
99% Cinepazide Maleate
✔
99% (HPLC) Terfenadine
✔
98% YM-58483
✔
99%+ Ranolazine
✔
98% Praeruptorin A
✔
p38 MAPK,Akt 98% Ranolazine 2HCl
✔
98% Felodipine
++++
L-type calcium channel, IC50: 0.15 nM
98% PD173212
+++
N-type Ca2+ channel, IC50: 36 nM
98% Levamlodipine besylate
✔
97% Carboxyamidotriazole Orotate
✔
98% IGS-1.76
✔
98+% WH-4-023
++++
++++
99%+ 展开 1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
N106 生物活性 描述 N106 is the first SERCA2a SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used in heart failure research to improve the contractile properties of cultured rat cardiomyocytes. N106 increases cell contractility, ATPase activity of calcium-transient SERCA2a, and SUMOylation within 10 minutes of administration, and these effects last for 24 hours in cardiomyocytes [1]
N106 动物研究 Animal study When administered intravenously at a dose of 10 mg/kg, N106 has a half-life of 65.4 min and a Cmax of 2.24 μM in a mouse model, with an oral bioavailability of 56% and a half-life (t1/2) of 19 min. In in vivo experiments, N106 increased cardiac SERCA2A SUMOylation and significantly improved ventricular function in heart failure mice[1]
N106 参考文献 N106 实验方案 计算器 摩尔计算器 总药量计算器 工作液计算器 存储液制备 1mg 5mg 10mg 1 mM
5 mM
10 mM
2.82mL
0.56mL
0.28mL
14.11mL
2.82mL
1.41mL
28.22mL
5.64mL
2.82mL
N106 技术信息
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