产品说明书
N106
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同义名 : | - |
| CAS号 : | 862974-25-2 | |
| 货号 : | A1231634 | |
| 分子式 : | C17H14N4O3S | |
| 纯度 : | 98% | |
| 分子量 : | 354.383 | |
| MDL号 : | MFCD05892638 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 60 mg/mL(169.31 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | N106 is the first SERCA2a SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used in heart failure research to improve the contractile properties of cultured rat cardiomyocytes. N106 increases cell contractility, ATPase activity of calcium-transient SERCA2a, and SUMOylation within 10 minutes of administration, and these effects last for 24 hours in cardiomyocytes [1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.82mL 0.56mL 0.28mL |
14.11mL 2.82mL 1.41mL |
28.22mL 5.64mL 2.82mL |
| 参考文献 |
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