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首页 / 抑制剂/激动剂 / 神经信号通路 / AChR / Methylbenactyzium Bromide

Methylbenactyzium Bromide {[allProObj[0].p_purity_real_show]}

货号：A293815 同义名： Semulgin;Paragone

Methylbenactyzium Bromide is a mAchR antagonist, used as a spasmolytic for the treatment of gastrointestinal ulcer and gastrointestinal spasms.

Methylbenactyzium Bromide 化学结构 CAS号：3166-62-9
Methylbenactyzium Bromide 化学结构
CAS号：3166-62-9
Methylbenactyzium Bromide 3D分子结构
CAS号：3166-62-9
Methylbenactyzium Bromide 化学结构 CAS号：3166-62-9
Methylbenactyzium Bromide 3D分子结构 CAS号：3166-62-9
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Methylbenactyzium Bromide 纯度/质量文件 产品仅供科研

货号：A293815 标准纯度： {[allProObj[0].p_purity_real_show]}
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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

hAChE, IC50: 11.6 nM

bAChE, IC50: 8.12 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 98%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine hydrochloride ✔ 97%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 98%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		98%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Methylbenactyzium Bromide 生物活性

描述 Methylbenactyzium Bromide is a muscarinic acetylcholine receptor (mAChR) inhibitor. Propantheline was highly bound to the membrane and this binding was inhibited to varying extents by several quaternary ammonium compounds. Mepenzolate and methylbenactyzium inhibited it significantly[2]. Methylbenactyzium bromide was extracted from urine with ODS-cartridge (Sep-Pak C18), then spotted onto a silica gel 60 F254 TLC plate. After development, the separated spot of methylbenactyzium bromide was scraped and wrapped with a ferromagnetic foil without extraction by any organic solvents. A calibration graph prepared by absolute calibration method showed a good linearity over the concentration range of 1-75 micrograms/spot for methylbenactyzium bromide. The coefficient of variation obtained for eleven replicate analyses of the 3 micrograms/spot of standard methylbenactyzium bromide was 3.8%. The detection limit of this compound by this procedure was 0.1 micrograms/spot[3].

Methylbenactyzium Bromide 参考文献

[1]Bhattacharjee AK, Pomponio JW, et al. Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods. Bioorg Med Chem. 2013;21(9):2651-62

[2]Saitoh H, Kobayashi Y, Miyazaki K, Arita T. A highly sensitive HPLC method for the assay of propantheline used to measure its uptake by rat intestinal brush border membrane vesicles. J Pharm Pharmacol. 1987;39(1):9-12

[3]Nishikawa M, Tatsuno M, Suzuki S, Tsuchihashi H. Analysis of methylbenactyzium bromide in human urine by thin-layer chromatography and pyrolysis gas chromatography. Forensic Sci Int. 1991;49(2):197-203

Methylbenactyzium Bromide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.84mL

2.37mL

1.18mL

23.68mL

4.74mL

2.37mL

Methylbenactyzium Bromide 技术信息

CAS号3166-62-9
分子式C21H28BrNO3
分子量 422.356
别名 Semulgin;Paragone;NSC11525;FWH101;Noinarin;Gastrimade;Methylbenactyzine Bromide
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 5 mg/mL(11.84 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(236.77 mM)，配合低频超声助溶
动物实验配方

Tags: Methylbenactyzium | 3166-62-9 | mAChR | Muscarinic acetylcholine receptor | mAChR Inhibitor | GPCR/G Protein | Neuronal Signaling | mAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Methylbenactyzium Bromide 纯度/质量文件 | Methylbenactyzium Bromide 亚型比较 | Methylbenactyzium Bromide 生物活性 | Methylbenactyzium Bromide 参考文献 | Methylbenactyzium Bromide 实验方案 | Methylbenactyzium Bromide 技术信息

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