产品说明书
Methylbenactyzium Bromide
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同义名 : | Semulgin;Paragone;NSC11525;FWH101;Noinarin;Gastrimade;Methylbenactyzine Bromide |
| CAS号 : | 3166-62-9 | |
| 货号 : | A293815 | |
| 分子式 : | C21H28BrNO3 | |
| 纯度 : | 99% | |
| 分子量 : | 422.356 | |
| MDL号 : | MFCD00210328 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 5 mg/mL(11.84 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(236.77 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Methylbenactyzium Bromide is a muscarinic acetylcholine receptor (mAChR) inhibitor. Propantheline was highly bound to the membrane and this binding was inhibited to varying extents by several quaternary ammonium compounds. Mepenzolate and methylbenactyzium inhibited it significantly[2]. Methylbenactyzium bromide was extracted from urine with ODS-cartridge (Sep-Pak C18), then spotted onto a silica gel 60 F254 TLC plate. After development, the separated spot of methylbenactyzium bromide was scraped and wrapped with a ferromagnetic foil without extraction by any organic solvents. A calibration graph prepared by absolute calibration method showed a good linearity over the concentration range of 1-75 micrograms/spot for methylbenactyzium bromide. The coefficient of variation obtained for eleven replicate analyses of the 3 micrograms/spot of standard methylbenactyzium bromide was 3.8%. The detection limit of this compound by this procedure was 0.1 micrograms/spot[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.37mL 0.47mL 0.24mL |
11.84mL 2.37mL 1.18mL |
23.68mL 4.74mL 2.37mL |
| 参考文献 |
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