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盐酸左旋咪唑 /Levamisole HCI {[allProObj[0].p_purity_real_show]}

货号:A121733 同义名: (-)-Tetramisole hydrochloride;(−)-Levamisole (hydrochloride)

Levamisole HCl is a nAChR agonist used as an anthelmintic to treat worm infestations.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Levamisole HCI 化学结构 CAS号:16595-80-5
Levamisole HCI 化学结构
CAS号:16595-80-5
Levamisole HCI 3D分子结构
CAS号:16595-80-5
Levamisole HCI 化学结构 CAS号:16595-80-5
Levamisole HCI 3D分子结构 CAS号:16595-80-5
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Levamisole HCI 纯度/质量文件 产品仅供科研

货号:A121733 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 AChE AChR mAChR nAChR 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

98%
Loganin ++

AChE, IC50: 3.95 μM

99%+
topride HCl ++

AChE, IC50: 2.04 μM

98%
Dehydroevodiamine HCl 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

99%+
Palmatine ++

AChE, IC50: 0.51 μM

98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

98%
Trospium chloride 99%
Tiotropium Bromide Monohydrate 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

98%
Hexamethonium Bromide 99%
Pancuronium dibromide 98%
Neostigmine bromide 98%
Orphenadrine citrate 98%
Oxybutynin 98%
Irsogladine PDE 98%
Pyridostigmine bromide 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

98%
Paroxetine hydrochloride 97%
Rocuronium Bromide 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

98%
Diphenmanil methylsulfate 98%
Umeclidinium bromide 95%
Otilonium bromide 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

98%
Ipratropium bromide 98%
Diphenidol HCl 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

98%
Oxybutynin chloride 99%
Pentoxyverine citrate 98%
Solifenacin 98%
Catharanthine 98%
Benzethonium chloride +++

α7 nAChRs, IC50: 122 nM

α4β2 nAChRs, IC50: 49 nM

99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Levamisole HCI 生物活性

描述 Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV. Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users[3]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform[4]. There was no benefit of a single-dose of levamisole hydrochloride as adjuvant to intravenous artesunate in the treatment of adults with severe falciparum malaria. Rapid parasite killing by intravenous artesunate might obscure the effects of levamisole[5]. Using BALB/c mice with experimental allergic rhinitis, levamisole delivered locally (intranasal, i.n.) could attenuate early-phase inflammatory response, decrease histamine, suppress edema and eosinophil infiltration, and diminish the ovalbumin-specific serum IgE level. Levamisole can decrease IL-4, IL-5 and IL-13 mRNA and increase IL-12, IL-18 and IFN-gamma mRNA[6].

Levamisole HCI 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03432364 Transfusion Dependent Beta-tha... 展开 >>lassemia 收起 << Phase 1 Phase 2 Recruiting May 2022 United States, California ... 展开 >> University of California, Los Angeles Recruiting Los Angeles, California, United States, 90095-1678 Contact: Nikki Alimi, ANP-BC    310-794-0242    NAlimi@mednet.ucla.edu    Contact: Bruck Habtemariam    310-794-0242    bhabtemariam@mednet.ucla.edu    Principal Investigator: Gary Schiller, M.D.          UCSF Benioff Children's Hospital Oakland Recruiting Oakland, California, United States, 94609 Contact: Julie Decaris    510-428-3885 ext 2739    jdecaris@mail.cho.org    Principal Investigator: Mark Walters, MD          United States, Massachusetts Dana-Farber Boston Children's Cancer and Blood Disorders Center Recruiting Boston, Massachusetts, United States, 02116 Contact: Colleen Dansereau, M.S.N., R.N.    617-919-7008    colleen.dansereau@childrens.harvard.edu    Principal Investigator: David A Williams, M.D.          United States, Minnesota University of Minnesota Recruiting Minneapolis, Minnesota, United States, 55455 Contact: Angela Smith, M.D., M.S.    612-625-7253    smith719@umn.edu    Contact: Jennifer Braun, R.N., BSN    612-625-0084    danie659@umn.edu    Principal Investigator: Angela Smith, M.D., M.S. 收起 <<
NCT03141970 Nephrotic Syndrome Phase 3 Recruiting March 31, 2022 United States, California ... 展开 >> Cedars-Sinai Medical Center, Pediatric IBD & Pediatric Nephrology Not yet recruiting Los Angeles, California, United States, 90048 Contact: Jessica Reece, MA    310-423-5314    jessica.reece@cshs.org    Principal Investigator: Elaine S Kamil, MD          Stanford University Medical Center, Department of Pediatrics, Division of Nephrology Not yet recruiting Stanford, California, United States, 94305 Contact: Maira Simas    650-725-8327    mnsimas@standford.edu    Principal Investigator: Gia J Oh, MD          United States, Michigan University of Michigan Department of Pedatric Nephrology Not yet recruiting Ann Arbor, Michigan, United States, 48109 Contact: Brenda S Buckle, MSN    734-232-4830    bbuckle@med.umich.edu    Contact: Hailey Desmond, MS    734 232 4830    heturner@med.umich.edu    Principal Investigator: Debbie Gipson, MD          United States, North Carolina Levine's Children/Carolinas HealthCare System Not yet recruiting Charlotte, North Carolina, United States, 28207 Contact: Jennifer Lamothe, RN,BSN,CCRC    704-347-4052    jennifer.lamothe@carolinas.org    Principal Investigator: Susan Massengill, MD          India All India Institute of Medical Sciences Recruiting New Delhi, Delhi, India, 110029 Contact: Arvind Bagga, MD    911126593472    arvindbagga@hotmail.com    Contact: Aditi Sinha, MD    919899145489    aditisinhaaiims@gmail.com    Principal Investigator: Arvind Bagga, MD          Sub-Investigator: Aditi Sinha, MD          Sub-Investigator: Pankaj Hari, MD 收起 <<
NCT02878564 Schistosomiasis Mansoni ... 展开 >> HIV 收起 << Phase 4 Completed - Uganda ... 展开 >> UVRI-IAVI HIV Vaccine program Entebbe, Wakiso, Uganda 收起 <<

Levamisole HCI 参考文献

[1]Khan FA, Sanyal PK, et al. Comparative anthelmintic activity of strategic sustained low-level administration of albendazole in feed pellets compared to single doses of closantel and tetramisole against natural ovine parasitic gastroenteritis. Trop Anim Health Prod. 1999 Aug;31(4):193-204.

[2]Blach-Olszewska Z, Zaczynska E. Influence of L-tetramisole on the interferon production by mouse peritoneal and L929 cells. Arch Immunol Ther Exp (Warsz). 1991;39(5-6):597-604.

[3]Zhu NY, Legatt DF, Turner AR. Agranulocytosis after consumption of cocaine adulterated with levamisole. Ann Intern Med. 2009 Feb 17;150(4):287-9

[4]Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976 Jul;22(7):972-6

[5]Maude RJ, Silamut K, Plewes K, Charunwatthana P, Ho M, Abul Faiz M, Rahman R, Hossain MA, Hassan MU, Bin Yunus E, Hoque G, Islam F, Ghose A, Hanson J, Schlatter J, Lacey R, Eastaugh A, Tarning J, Lee SJ, White NJ, Chotivanich K, Day NP, Dondorp AM. Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia. J Infect Dis. 2014 Jan 1;209(1):120-9

[6]Wang H, Zhang J, Gao C, Zhu Y, Wang C, Zheng W. Topical levamisole hydrochloride therapy attenuates experimental murine allergic rhinitis. Eur J Pharmacol. 2007 Dec 22;577(1-3):162-9

Levamisole HCI 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.15mL

0.83mL

0.42mL

20.77mL

4.15mL

2.08mL

41.54mL

8.31mL

4.15mL

Levamisole HCI 技术信息

CAS号16595-80-5
分子式C11H13ClN2S
分子量 240.752
别名 (-)-Tetramisole hydrochloride;(−)-Levamisole (hydrochloride);L-Tetramisole;R 12654;NSC 177023
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 15 mg/mL(62.3 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(207.68 mM),配合低频超声助溶

无水乙醇: 12.5 mg/mL(51.92 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇

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