产品说明书
Levamisole HCI
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同义名 : | (-)-Tetramisole hydrochloride;(−)-Levamisole (hydrochloride);L-Tetramisole;R 12654;NSC 177023 |
| CAS号 : | 16595-80-5 | |
| 货号 : | A121733 | |
| 分子式 : | C11H13ClN2S | |
| 纯度 : | 97% | |
| 分子量 : | 240.752 | |
| MDL号 : | MFCD00012675 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 15 mg/mL(62.3 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(207.68 mM)，配合低频超声助溶 无水乙醇: 12.5 mg/mL(51.92 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV. Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users[3]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform[4]. There was no benefit of a single-dose of levamisole hydrochloride as adjuvant to intravenous artesunate in the treatment of adults with severe falciparum malaria. Rapid parasite killing by intravenous artesunate might obscure the effects of levamisole[5]. Using BALB/c mice with experimental allergic rhinitis, levamisole delivered locally (intranasal, i.n.) could attenuate early-phase inflammatory response, decrease histamine, suppress edema and eosinophil infiltration, and diminish the ovalbumin-specific serum IgE level. Levamisole can decrease IL-4, IL-5 and IL-13 mRNA and increase IL-12, IL-18 and IFN-gamma mRNA[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03432364 | Transfusion Dependent Beta-tha... 展开 >>lassemia 收起 << | Phase 1 Phase 2 | Recruiting | May 2022 | United States, California ... 展开 >> University of California, Los Angeles Recruiting Los Angeles, California, United States, 90095-1678 Contact: Nikki Alimi, ANP-BC 310-794-0242 NAlimi@mednet.ucla.edu Contact: Bruck Habtemariam 310-794-0242 bhabtemariam@mednet.ucla.edu Principal Investigator: Gary Schiller, M.D. UCSF Benioff Children's Hospital Oakland Recruiting Oakland, California, United States, 94609 Contact: Julie Decaris 510-428-3885 ext 2739 jdecaris@mail.cho.org Principal Investigator: Mark Walters, MD United States, Massachusetts Dana-Farber Boston Children's Cancer and Blood Disorders Center Recruiting Boston, Massachusetts, United States, 02116 Contact: Colleen Dansereau, M.S.N., R.N. 617-919-7008 colleen.dansereau@childrens.harvard.edu Principal Investigator: David A Williams, M.D. United States, Minnesota University of Minnesota Recruiting Minneapolis, Minnesota, United States, 55455 Contact: Angela Smith, M.D., M.S. 612-625-7253 smith719@umn.edu Contact: Jennifer Braun, R.N., BSN 612-625-0084 danie659@umn.edu Principal Investigator: Angela Smith, M.D., M.S. 收起 << |
| NCT03141970 | Nephrotic Syndrome | Phase 3 | Recruiting | March 31, 2022 | United States, California ... 展开 >> Cedars-Sinai Medical Center, Pediatric IBD & Pediatric Nephrology Not yet recruiting Los Angeles, California, United States, 90048 Contact: Jessica Reece, MA 310-423-5314 jessica.reece@cshs.org Principal Investigator: Elaine S Kamil, MD Stanford University Medical Center, Department of Pediatrics, Division of Nephrology Not yet recruiting Stanford, California, United States, 94305 Contact: Maira Simas 650-725-8327 mnsimas@standford.edu Principal Investigator: Gia J Oh, MD United States, Michigan University of Michigan Department of Pedatric Nephrology Not yet recruiting Ann Arbor, Michigan, United States, 48109 Contact: Brenda S Buckle, MSN 734-232-4830 bbuckle@med.umich.edu Contact: Hailey Desmond, MS 734 232 4830 heturner@med.umich.edu Principal Investigator: Debbie Gipson, MD United States, North Carolina Levine's Children/Carolinas HealthCare System Not yet recruiting Charlotte, North Carolina, United States, 28207 Contact: Jennifer Lamothe, RN,BSN,CCRC 704-347-4052 jennifer.lamothe@carolinas.org Principal Investigator: Susan Massengill, MD India All India Institute of Medical Sciences Recruiting New Delhi, Delhi, India, 110029 Contact: Arvind Bagga, MD 911126593472 arvindbagga@hotmail.com Contact: Aditi Sinha, MD 919899145489 aditisinhaaiims@gmail.com Principal Investigator: Arvind Bagga, MD Sub-Investigator: Aditi Sinha, MD Sub-Investigator: Pankaj Hari, MD 收起 << |
| NCT02878564 | Schistosomiasis Mansoni ... 展开 >> HIV 收起 << | Phase 4 | Completed | - | Uganda ... 展开 >> UVRI-IAVI HIV Vaccine program Entebbe, Wakiso, Uganda 收起 << |
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.15mL 0.83mL 0.42mL |
20.77mL 4.15mL 2.08mL |
41.54mL 8.31mL 4.15mL |
| 参考文献 |
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