生物活性 | |||
---|---|---|---|
靶点 |
|
||
描述 | Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM[3]. At low frequencies of stimulation (0.5-2 Hz), hexamethonium (200 mM) and methyllycaconitine (2.0 mM) increased e.p.c. quantal content by 30-40%. The low frequency augmentation of e.p.c. quantal content by hexamethonium was absent when extracellular [Ca2+] was lowered from 2.0 to 0.5 mM[4]. |
临床研究 | |||||
---|---|---|---|---|---|
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03360136 | Exhaustion; Syndrome ... 展开 >> Burnout, Professional Burnout Syndrome Adjustment Disorders 收起 << | Not Applicable | Recruiting | July 1, 2020 | Sweden ... 展开 >> PBM Sweden AB Globen Recruiting Stockholm, Södermanland, Sweden, 12177 Contact: Gunilla Brodda Jansen, Assoc. Proff. 070-716 39 13 ext +46 gunillabroddajansen@pbm.se PBM Sweden City Recruiting Stockholm, Uppland, Sweden, 114 47 Contact: Gunilla Brodda Jansen, Assoc. Proff. 070-716 39 13 ext +46 gunillabroddajansen@pbm.se 收起 << |
NCT03468114 | Enteric Infections ... 展开 >> Diarrhea 收起 << | Not Applicable | Recruiting | December 2018 | Kenya ... 展开 >> Great Lakes University Kisumu Recruiting Kisumu, Kenya Contact: Sheillah Simiyu, PhD +254 722 215291 sheillahshie@gmail.com 收起 << |
NCT01626703 | Depression Sc... 展开 >>reening Elderly 收起 << | Not Applicable | Completed | - | Korea, Republic of ... 展开 >> Chungju community health care center Chungju, Choongbuk, Korea, Republic of, 123456 收起 << |
实验方案 | |||
---|---|---|---|
1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.76mL 0.55mL 0.28mL |
13.80mL 2.76mL 1.38mL |
27.61mL 5.52mL 2.76mL |
参考文献 |
---|