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Hexamethonium Bromide

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Chemical Structure| 55-97-0 同义名 : 溴化六甲铵 ;Hexamethonium (bromide);Hexamethonium Dibromide
CAS号 : 55-97-0
货号 : A139736
分子式 : C12H30Br2N2
纯度 : 99%
分子量 : 362.188
MDL号 : MFCD00011787
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(44.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(276.1 mM)
动物实验配方：

PO 0.5% CMC-Na 100 mg/mL clear

生物活性
靶点

  • AChR
描述 Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM[3]. At low frequencies of stimulation (0.5-2 Hz), hexamethonium (200 mM) and methyllycaconitine (2.0 mM) increased e.p.c. quantal content by 30-40%. The low frequency augmentation of e.p.c. quantal content by hexamethonium was absent when extracellular [Ca2+] was lowered from 2.0 to 0.5 mM[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03360136 Exhaustion; Syndrome ... 展开 >> Burnout, Professional Burnout Syndrome Adjustment Disorders 收起 << Not Applicable Recruiting July 1, 2020 Sweden ... 展开 >> PBM Sweden AB Globen Recruiting Stockholm, Södermanland, Sweden, 12177 Contact: Gunilla Brodda Jansen, Assoc. Proff.    070-716 39 13 ext +46    gunillabroddajansen@pbm.se    PBM Sweden City Recruiting Stockholm, Uppland, Sweden, 114 47 Contact: Gunilla Brodda Jansen, Assoc. Proff.    070-716 39 13 ext +46    gunillabroddajansen@pbm.se 收起 <<
NCT03468114 Enteric Infections ... 展开 >> Diarrhea 收起 << Not Applicable Recruiting December 2018 Kenya ... 展开 >> Great Lakes University Kisumu Recruiting Kisumu, Kenya Contact: Sheillah Simiyu, PhD    +254 722 215291    sheillahshie@gmail.com 收起 <<
NCT01626703 Depression Sc... 展开 >>reening Elderly 收起 << Not Applicable Completed - Korea, Republic of ... 展开 >> Chungju community health care center Chungju, Choongbuk, Korea, Republic of, 123456 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.76mL

0.55mL

0.28mL

13.80mL

2.76mL

1.38mL

27.61mL

5.52mL

2.76mL
参考文献

[1]Tian L, Prior C, et al. Hexamethonium- and methyllycaconitine-induced changes in acetylcholine release from rat motor nerve terminals. Br J Pharmacol. 1997 Nov;122(6):1025-34.

[2]Rang HP, Rylett RJ. The interaction between hexamethonium and tubocurarine on the rat neuromuscular junction. Br J Pharmacol. 1984 Mar;81(3):519-31.

[3]Rang HP, Rylett RJ. The interaction between hexamethonium and tubocurarine on the rat neuromuscular junction. Br J Pharmacol. 1984 Mar;81(3):519-31.

[4]Tian L, Prior C, Dempster J, Marshall IG. Hexamethonium- and methyllycaconitine-induced changes in acetylcholine release from rat motor nerve terminals. Br J Pharmacol. 1997 Nov;122(6):1025-34.