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Gallamine Triethiodide

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Chemical Structure| 65-29-2 同义名 : 加拉碘铵 ;Gallamine (iodide)
CAS号 : 65-29-2
货号 : A616170
分子式 : C30H60I3N3O3
纯度 : 98%
分子量 : 891.529
MDL号 : MFCD00011832
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:1个月-80°C:12个月
溶解度 :

H2O: 30 mg/mL(33.65 mM)
动物实验配方：
生物活性
靶点

  • AChR

    AChR, IC50:68.0 μM
描述 Gallamine Triethiodine is a cholinergic receptor inhibitor. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release[3]. Internal gallamine triethiodide modifies Na+ channel kinetics in Myxicola axons but does not alter K+ conductance[4]. Slight accumulation of gallamine was noted in two of the four patients with biliary disease receiving multiple doses of gallamine, but this was also characteristic of data obtained in the patients without obstruction[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.12mL

0.22mL

0.11mL

5.61mL

1.12mL

0.56mL

11.22mL

2.24mL

1.12mL
参考文献

[1]Abbas MN, Mostafa GA. Gallamine-tetraphenylborate-modified carbon paste electrode for the potentiometric determination of gallamine triethiodide(flaxedil). J Pharm Biomed Anal. 2003 Mar 26;31(4):819-26.

[2]Nedoma J, Tucek S, et al. Stabilization of antagonist binding to cardiac muscarinic acetylcholine receptors by gallamine and other neuromuscular blocking drugs. J Pharmacol Exp Ther. 1986 Jan;236(1):219-23.

[3]SMITH RH, THOMAS DL. Gallamine triethiodide as an adjunct to electroplexy. Br Med J. 1951 Apr 21;1(4711):860-2.

[4]Schauf CL, Smith KJ. Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons. J Physiol. 1982 Feb;323:157-71.

[5]Ramzan IM, Shanks CA, Triggs EJ. Pharmacokinetics and pharmacodynamics of gallamine triethiodide in patients with total biliary obstruction. Anesth Analg. 1981 May;60(5):289-96.