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帕金森与阿尔茨海默症
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/ Aniracetam

茴拉西坦 /Aniracetam {[allProObj[0].p_purity_real_show]}

货号：A890956 同义名： 阿尼西坦 / Ro 13-5057;Memodrin Ambeed 开学季，买赠积分，赢豪礼

Aniracetam is an allosteric modulator of AMPAR which can reduce glutamate receptor desensitization and potentiate metabotropic glutamate receptor activity.

Aniracetam 化学结构 CAS号：72432-10-1
Aniracetam 化学结构
CAS号：72432-10-1
Aniracetam 3D分子结构
CAS号：72432-10-1
Aniracetam 化学结构 CAS号：72432-10-1
Aniracetam 3D分子结构 CAS号：72432-10-1
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Aniracetam 纯度/质量文件 产品仅供科研

货号：A890956 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		{[allProObj[0].p_purity_real_show]}
Loganin ++

AChE, IC50: 3.95 μM

 		{[allProObj[0].p_purity_real_show]}
topride HCl ++

AChE, IC50: 2.04 μM

 		{[allProObj[0].p_purity_real_show]}
Dehydroevodiamine HCl ✔ {[allProObj[0].p_purity_real_show]}
Jatrorrhizine ++

AChE, IC50: 872 nM

 		{[allProObj[0].p_purity_real_show]}
Palmatine ++

AChE, IC50: 0.51 μM

 		{[allProObj[0].p_purity_real_show]}
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		{[allProObj[0].p_purity_real_show]}
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		{[allProObj[0].p_purity_real_show]}
Trospium chloride ✔ {[allProObj[0].p_purity_real_show]}
Tiotropium Bromide Monohydrate ✔ {[allProObj[0].p_purity_real_show]}
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		{[allProObj[0].p_purity_real_show]}
Hexamethonium Bromide ✔ {[allProObj[0].p_purity_real_show]}
Pancuronium dibromide ✔ {[allProObj[0].p_purity_real_show]}
Neostigmine bromide ✔ {[allProObj[0].p_purity_real_show]}
Orphenadrine citrate ✔ {[allProObj[0].p_purity_real_show]}
Oxybutynin ✔ {[allProObj[0].p_purity_real_show]}
Irsogladine ✔ PDE {[allProObj[0].p_purity_real_show]}
Pyridostigmine bromide ✔ {[allProObj[0].p_purity_real_show]}
Rivastigmine +

AChR, IC50: 5.5 μM

 		{[allProObj[0].p_purity_real_show]}
Paroxetine hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Rocuronium Bromide ✔ {[allProObj[0].p_purity_real_show]}
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		{[allProObj[0].p_purity_real_show]}
Diphenmanil methylsulfate ✔ {[allProObj[0].p_purity_real_show]}
Umeclidinium bromide ✔ {[allProObj[0].p_purity_real_show]}
Otilonium bromide ✔ {[allProObj[0].p_purity_real_show]}
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		{[allProObj[0].p_purity_real_show]}
Ipratropium bromide ✔ {[allProObj[0].p_purity_real_show]}
Diphenidol HCl ✔ {[allProObj[0].p_purity_real_show]}
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		{[allProObj[0].p_purity_real_show]}
Aclidinium Bromide ++++

M2 mAChR, Ki: 0.1 nM

M4 mAChR, Ki: 0.21 nM

 		{[allProObj[0].p_purity_real_show]}
Oxybutynin chloride ✔ {[allProObj[0].p_purity_real_show]}
Pentoxyverine citrate ✔ {[allProObj[0].p_purity_real_show]}
Solifenacin ✔ {[allProObj[0].p_purity_real_show]}
Catharanthine ✔ {[allProObj[0].p_purity_real_show]}
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		{[allProObj[0].p_purity_real_show]}
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		{[allProObj[0].p_purity_real_show]}
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Aniracetam 生物活性

描述 Aniracetam is another AMPAkine created by modifying the piracetam molecule by replacing the acetamide moiety with a 4-methoxybenzoyl group.aniracetam improved healthy rats’ performance on active avoidance tasks, and on radial arm maze tasks [3]. Physiologically, aniracetam enhances both glutamatergic neurotransmission and long-term potentiation.But aniracetam does not alter behavior in normal healthy mice[4].Further, aniracetam (a nootropic compound with glutamatergic activity and neuroprotective potential) is a promising option for patients with cognitive deficit of mild severity[5].

Aniracetam 参考文献

[1]Vaglenova J, Pandiella N, et al. Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology. 2008 Apr;33(5):1071-83. Epub 2007 Jul 4.

[2]Nakamura K, Kurasawa M. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43.

[3]Phillips H, McDowell A, Mielby BS, Tucker IG, Colombo M. Aniracetam does not improve working memory in neurologically healthy pigeons. PLoS One. 2019 Apr 19;14(4):e0215612. doi: 10.1371/journal.pone.0215612. PMID: 31002681; PMCID: PMC6474613.

[4]Elston TW, Pandian A, Smith GD, Holley AJ, Gao N, Lugo JN. Aniracetam does not alter cognitive and affective behavior in adult C57BL/6J mice. PLoS One. 2014 Aug 6;9(8):e104443. doi: 10.1371/journal.pone.0104443. PMID: 25099639; PMCID: PMC4123976.

[5]Koliaki CC, Messini C, Tsolaki M. Clinical efficacy of aniracetam, either as monotherapy or combined with cholinesterase inhibitors, in patients with cognitive impairment: a comparative open study. CNS Neurosci Ther. 2012 Apr;18(4):302-12. doi: 10.1111/j.1755-5949.2010.00244.x. Epub 2011 Feb 26. PMID: 22070796; PMCID: PMC6493642.

Aniracetam 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.56mL

0.91mL

0.46mL

22.81mL

4.56mL

2.28mL

45.61mL

9.12mL

4.56mL

Aniracetam 技术信息

CAS号72432-10-1
分子式C12H13NO3
分子量 219.237
别名 阿尼西坦 ;Ro 13-5057;Memodrin;Draganon;Ampamet;Sarpul
运输蓝冰
存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(478.93 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

PO 0.5% CMC-Na 80 mg/mL clear

Tags: Aniracetam | 72432-10-1 | Ro 13-5057 | Membrane Transporter/Ion Channel | Neuronal Signaling | nAChR | iGluR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Aniracetam 纯度/质量文件 | Aniracetam 亚型比较 | Aniracetam 生物活性 | Aniracetam 参考文献 | Aniracetam 实验方案 | Aniracetam 技术信息

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