产品说明书

Aniracetam

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Chemical Structure| 72432-10-1 同义名 : 阿尼西坦 ;Ro 13-5057;Memodrin;Draganon;Ampamet;Sarpul
CAS号 : 72432-10-1
货号 : A890956
分子式 : C12H13NO3
纯度 : 97%
分子量 : 219.237
MDL号 : MFCD00153767
存储条件:

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(478.93 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:

PO 0.5% CMC-Na 80 mg/mL clear

生物活性
描述 Aniracetam is another AMPAkine created by modifying the piracetam molecule by replacing the acetamide moiety with a 4-methoxybenzoyl group.aniracetam improved healthy rats’ performance on active avoidance tasks, and on radial arm maze tasks [3]. Physiologically, aniracetam enhances both glutamatergic neurotransmission and long-term potentiation.But aniracetam does not alter behavior in normal healthy mice[4].Further, aniracetam (a nootropic compound with glutamatergic activity and neuroprotective potential) is a promising option for patients with cognitive deficit of mild severity[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.56mL

0.91mL

0.46mL

22.81mL

4.56mL

2.28mL

45.61mL

9.12mL

4.56mL

参考文献

[1]Vaglenova J, Pandiella N, et al. Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology. 2008 Apr;33(5):1071-83. Epub 2007 Jul 4.

[2]Nakamura K, Kurasawa M. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43.

[3]Phillips H, McDowell A, Mielby BS, Tucker IG, Colombo M. Aniracetam does not improve working memory in neurologically healthy pigeons. PLoS One. 2019 Apr 19;14(4):e0215612. doi: 10.1371/journal.pone.0215612. PMID: 31002681; PMCID: PMC6474613.

[4]Elston TW, Pandian A, Smith GD, Holley AJ, Gao N, Lugo JN. Aniracetam does not alter cognitive and affective behavior in adult C57BL/6J mice. PLoS One. 2014 Aug 6;9(8):e104443. doi: 10.1371/journal.pone.0104443. PMID: 25099639; PMCID: PMC4123976.

[5]Koliaki CC, Messini C, Tsolaki M. Clinical efficacy of aniracetam, either as monotherapy or combined with cholinesterase inhibitors, in patients with cognitive impairment: a comparative open study. CNS Neurosci Ther. 2012 Apr;18(4):302-12. doi: 10.1111/j.1755-5949.2010.00244.x. Epub 2011 Feb 26. PMID: 22070796; PMCID: PMC6493642.