9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs calledtopoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.
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9-Aminocamptothecin, an inhibitor of topoisomerase I, exhibits strong anticancer properties. In cancer cell lines from such as breast (MCF-7), bladder (MGH-U1), and colon (HT-29), the cytotoxic effects of 9-Aminocamptothecin escalate with increased drug concentrations and prolonged exposure periods. Notably, minimal cell death occurs unless the concentration of 9-Aminocamptothecin surpasses a threshold of 2.7 nM[1]. 9-Aminocamptothecin demonstrates inhibition of PC-3, PC-3M, DU145, and LNCaP cells, with IC50 values of 34.1 nM, 10 nM, 6.5 nM, and 8.9 nM respectively, following a drug exposure period of 96 hours[2].
9-Aminocamptothecin 动物研究
Animal study
9-Aminocamptothecin (9-Amino-CPT) curtails tumor growth at the minimal oral dosage of 0.35 mg/kg/day, while higher oral dosages of 0.75 and 1 mg/kg/day and subcutaneous administration at 4 mg/kg/week lead to tumor regression. The compound is well-tolerated across all dosages, with no instances of toxic death or weight loss exceeding 10% in any treatment group[2]. 9-Aminocamptothecin leads to complete remissions in 55% of SCID mice implanted with human myeloid leukemia. Both oral and intravenous administration methods prove to be equally efficacious. These findings from the pre-clinical model advocate for the assessment of 9-Aminocamptothecin as an antileukemic agent in a phase I clinical trial for patients with AML[3].
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Emory University Hospital - Atlanta
Atlanta, Georgia, United States, 30322
Emory University School of Medicine
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Yale Comprehensive Cancer Center
New Haven, Connecticut, United States, 06520-8028
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Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, United States, 60611
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New England Medical Center Hospital
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Emory University Hospital - Atlanta
Atlanta, Georgia, United States, 30322
Emory University School of Medicine
Atlanta, Georgia, United States, 30322 收起 <<
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Yale Comprehensive Cancer Center
New Haven, Connecticut, United States, 06520-8028
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Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, United States, 60611
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New England Medical Center Hospital
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Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106-5065 收起 <<
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Walter Reed Army Medical Center
Washington, District of Columbia, United States, 20307-5000
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University of Minnesota Cancer Center
Minneapolis, Minnesota, United States, 55455
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Washington University Barnard Cancer Center
Saint Louis, Missouri, United States, 63110
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Cooper Cancer Institute
Camden, New Jersey, United States, 08103
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Chicago, Illinois, United States, 60637-1470
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Chicago, Illinois, United States, 60640
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Decatur, Illinois, United States, 62526
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Peoria, Illinois, United States, 61602
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Springfield, Illinois, United States, 62701
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Fort Wayne Medical Oncology and Hematology, Inc.
Fort Wayne, Indiana, United States, 46885-5099
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South Bend, Indiana, United States, 46617 收起 <<
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Massachusetts General Hosptial
Boston, Massachusetts, United States, 02114
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Red Bank, New Jersey, United States, 07701
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Summit, New Jersey, United States, 07902-0220
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Bronx, New York, United States, 10461
NYU School of Medicine's Kaplan Comprehensive Cancer Center
New York, New York, United States, 10016
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New York, New York, United States, 10021
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