7-Ethylcamptothecin | SN-22 | Anticancer Agent | AmBeed-信号通路专用抑制剂

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7-乙基喜树碱 /7-Ethylcamptothecin 99%

货号：A154645 同义名： SN-22

7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I (topoisomerase).

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7-Ethylcamptothecin 化学结构
CAS号：78287-27-1

7-Ethylcamptothecin 3D分子结构
CAS号：78287-27-1

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7-Ethylcamptothecin 纯度/质量文件产品仅供科研

货号：A154645 标准纯度： 99% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

拓扑异构酶亚型比较

产品名称	Topo I ↓ ↑	Topo II ↓ ↑	Topo IV ↓ ↑	Topoisomerase ↓ ↑	其他靶点	纯度
Ellagic acid	✔					99%+
β-Lapachone	✔					99%+
(s)-10-hydroxycamptothecin	✔					99%+
Camptothecin	++ Topo I, IC50: 0.68 μM					98%
Betulinic acid	++ Eukaryotic topoisomerase I, IC50: 5 μM					99%+
Topotecan	++++ Topo I (DU-145 Luc cells), IC50: 2 nM Topo I (MCF-7 Luc cells), IC50: 13 nM					99%+
Irinotecan HCl Trihydrate	✔					98%
SN-38	✔					98%
Levofloxacin hydrate		✔				99%+
Dexrazoxane		✔				99%+
Ofloxacin		✔				98+%
Enoxacin		✔				99%+
Flumequine		+ Topo II, IC50: 15 μM				99%+
Levofloxacin		✔				99%+
Etoposide		✔				98%
Pefloxacin mesylate dihydrate		✔				99+%
Marbofloxacin		✔				99%+
Voreloxin HCl		✔				98%
Mitoxantrone dihydrochloride		✔			PKC	99%+
Nalidixic acid		✔				99%+
Doxorubicin		✔				98%
Novobiocin sodium		✔				98%+
Amonafide		✔				99%+
Pirarubicin		✔				98%+
Idarubicin HCl		+++ Topo II (MCF-7 cells), IC50: 3.3 ng/mL				99%+
Genistein		✔			EGFR	98%
Teniposide		✔				98%
Moxifloxacin		✔				98%
Ciprofloxacin			✔			99%+
Clinafloxacin			✔			97%
Gatifloxacin				✔		99%+
Daunorubicin HCl				+++ DNA synthesis, Ki: 20 nM		98%
Epirubicin HCl				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

7-Ethylcamptothecin 生物活性

描述	7-Ethylcamptothecin is a camptothecin derivative and an anti-cancer chemical which exhibited a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.

7-Ethylcamptothecin 参考文献

[1]Yaegashi T, Sawada S, et al. Chemical modification of antitumor alkaloids, 20(S)-camptothecin and 7-ethylcamptothecin: reaction of the E-lactone ring portion with hydrazine hydrate. Chem Pharm Bull (Tokyo). 1993 May;41(5):971-4.

[2]Nagata H, Kaneda N, et al. Action of 7-ethylcamptothecin on tumor cells and its disposition in mice. Cancer Treat Rep. 1987 Apr;71(4):341-8.

7-Ethylcamptothecin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.28mL

2.66mL

1.33mL

26.57mL

5.31mL

2.66mL

7-Ethylcamptothecin 技术信息

CAS号	78287-27-1
分子式	C₂₂H₂₀N₂O₄
分子量	376.405

别名	SN-22
运输	蓝冰

存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 4 mg/mL(10.63 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

7-乙基喜树碱 /7-Ethylcamptothecin 99%

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7-Ethylcamptothecin 质控信息

7-Ethylcamptothecin 生物活性

7-Ethylcamptothecin 参考文献

7-Ethylcamptothecin 实验方案

7-Ethylcamptothecin 技术信息

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7-乙基喜树碱 /7-Ethylcamptothecin 99%

7-Ethylcamptothecin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

7-Ethylcamptothecin 质控信息

7-Ethylcamptothecin 生物活性

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7-Ethylcamptothecin 实验方案

7-Ethylcamptothecin 技术信息

最近浏览的产品

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