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/ 7-Ethylcamptothecin

7-乙基喜树碱 /7-Ethylcamptothecin {[allProObj[0].p_purity_real_show]}

货号：A154645 同义名： SN-22

7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I (topoisomerase).

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7-Ethylcamptothecin 化学结构 CAS号：78287-27-1
7-Ethylcamptothecin 化学结构
CAS号：78287-27-1
7-Ethylcamptothecin 3D分子结构
CAS号：78287-27-1
7-Ethylcamptothecin 化学结构 CAS号：78287-27-1
7-Ethylcamptothecin 3D分子结构 CAS号：78287-27-1
规格 价格 会员价 库存 数量
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7-Ethylcamptothecin 纯度/质量文件 产品仅供科研

货号：A154645 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone dihydrochloride ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 98%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 97%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

7-Ethylcamptothecin 生物活性

描述 7-Ethylcamptothecin is a camptothecin derivative and an anti-cancer chemical which exhibited a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.

7-Ethylcamptothecin 参考文献

[1]Yaegashi T, Sawada S, et al. Chemical modification of antitumor alkaloids, 20(S)-camptothecin and 7-ethylcamptothecin: reaction of the E-lactone ring portion with hydrazine hydrate. Chem Pharm Bull (Tokyo). 1993 May;41(5):971-4.

[2]Nagata H, Kaneda N, et al. Action of 7-ethylcamptothecin on tumor cells and its disposition in mice. Cancer Treat Rep. 1987 Apr;71(4):341-8.

7-Ethylcamptothecin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.28mL

2.66mL

1.33mL

26.57mL

5.31mL

2.66mL

7-Ethylcamptothecin 技术信息

CAS号78287-27-1
分子式C22H20N2O4
分子量 376.405
别名 SN-22
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 4 mg/mL(10.63 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: 7-Ethylcamptothecin | 78287-27-1 | ADC Cytotoxin | ADC Payload | Antibody-drug Conjugate/ADC Related | ADC Cytotoxin | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 7-Ethylcamptothecin 纯度/质量文件 | 7-Ethylcamptothecin 亚型比较 | 7-Ethylcamptothecin 生物活性 | 7-Ethylcamptothecin 参考文献 | 7-Ethylcamptothecin 实验方案 | 7-Ethylcamptothecin 技术信息

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