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盐酸苯海索 /Trihexyphenidyl hydrochloride {[allProObj[0].p_purity_real_show]}

货号：A676555 同义名： 三己芬迪盐酸盐 / Trihexyphenidyl (hydrochloride);Benzhexol hydrochloride

Trihexyphenidyl hydrochloride是一种抗帕金森病药物，通过结合 M1 胆碱能受体发挥作用。

Trihexyphenidyl hydrochloride 化学结构 CAS号：52-49-3
Trihexyphenidyl hydrochloride 化学结构
CAS号：52-49-3
Trihexyphenidyl hydrochloride 3D分子结构
CAS号：52-49-3
Trihexyphenidyl hydrochloride 化学结构 CAS号：52-49-3
Trihexyphenidyl hydrochloride 3D分子结构 CAS号：52-49-3
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Trihexyphenidyl hydrochloride 纯度/质量文件 产品仅供科研

货号：A676555 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 97%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 99%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine hydrochloride ✔ 99%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 99%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		99%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M2 mAChR, Ki: 0.1 nM

M4 mAChR, Ki: 0.21 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Trihexyphenidyl hydrochloride 生物活性

描述 Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor. Trihexyphenidyl (THP) is an anticholinergic drug misused to procure hallucination, sedation, and anxiolysis[3]. Trihexyphenidyl Hydrochloride is a highly permeable drug and the transport mechanism is mainly via passive diffusion[4]. The majority of patients (dystonia in children with cerebral palsy) tolerated trihexyphenidyl well on a schedule of gradual dose increases, and almost all demonstrated improvements in dystonia or sialorrhea or both[5]. 2011;44(3):202‐206|. Trihexyphenidyl is consumed in association with alcohol, other licit drugs (benzodiazepines), or illicit drugs, impairing cognitive functions such as memory, attention, and learning, intervening with some activities of users' daily life[6].

Trihexyphenidyl hydrochloride 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01361373 Dystonic Cerebral Palsy Phase 4 Unknown August 2012 Israel ... 展开 >> Shaare Zedek Medical Center Recruiting Jerusalem, Israel Contact: Hilla Ben- Pazi, MD       Benpazi@gmail.com 收起 <<
NCT03430596 Extrapyramidal Syndrome Early Phase 1 Not yet recruiting June 2019 China, Shanghai ... 展开 >> Shanghai Mental Health Center Shanghai, Shanghai, China, 200030 收起 <<
NCT00122044 Dystonia Phase 2 Completed - United States, Alabama ... 展开 >> University of Alabama School of Medicine Birmingham, Alabama, United States, 35233 United States, California Stanford University Stanford, California, United States, 94305-5235 United States, Illinois Rehabilitation Institute of Chicago Chicago, Illinois, United States, 60611 United States, Maryland Kennedy Krieger Institute Baltimore, Maryland, United States, 21205 United States, Missouri Washington University School of Medicine St. Louis, Missouri, United States, 63110 United States, New York University of Rochester Medical Center Rochester, New York, United States, 14642 United States, Texas Texas Scottish Rite Hospital for Children Dallas, Texas, United States, 75219 收起 <<

Trihexyphenidyl hydrochloride 参考文献

[1]Huang Y, Zhao Z, et al. Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer's disease. J Neuroinflammation. 2016 Jul 1;13(1):175.

[2]Amal M. Moustafa, et al. The Egyptian Journal of Histology. 2011, 34:687-696.

[3]Torrents R, Ferré JF, Konareff A, et al. Misuse of Trihexyphenidyl (Artane) on Réunion Island. J Clin Psychopharmacol. 2018;38(3):250‐253

[4]Lu C, Fu K, Cao K, et al. Permeability and transport mechanism of trihexyphenidyl hydrochloride in Caco-2 cell monolayer model with a validated UPLC-MS/MS method. J Pharm Biomed Anal. 2020;178:112924

[5]Carranza-del Rio J, Clegg NJ, Moore A, Delgado MR. Use of trihexyphenidyl in children with cerebral palsy. Pediatr Neuro

[6]Nappo SA, de Oliveira LG, Sanchez Zv, Carlini Ede A. Trihexyphenidyl (Artane): a Brazilian study of its abuse. Subst Use Misuse. 2005;40(4):473‐482

Trihexyphenidyl hydrochloride 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.80mL

2.96mL

1.48mL

29.59mL

5.92mL

2.96mL

Trihexyphenidyl hydrochloride 技术信息

CAS号52-49-3
分子式C20H32ClNO
分子量 337.927
别名 三己芬迪盐酸盐 ;Trihexyphenidyl (hydrochloride);Benzhexol hydrochloride;Artane hydrochloride
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Room Temperature
溶解方案

DMSO: 9 mg/mL(26.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 5 mg/mL(14.8 mM)，配合低频超声，并水浴加热至45℃助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

Tags: Trihexyphenidyl hydrochloride | Trihexyphenidyl (hydrochloride);Benzhexol hydrochloride;Artane hydrochloride | 三己芬迪盐酸盐 | AChR | AmBeed-信号通路专用抑制剂 | Trihexyphenidyl hydrochloride 纯度/质量文件 | Trihexyphenidyl hydrochloride 亚型比较 | Trihexyphenidyl hydrochloride 生物活性 | Trihexyphenidyl hydrochloride 临床数据 | Trihexyphenidyl hydrochloride 参考文献 | Trihexyphenidyl hydrochloride 实验方案 | Trihexyphenidyl hydrochloride 技术信息

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