产品说明书

Pinaverium bromide

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Chemical Structure| 53251-94-8 同义名 : Icosapentaenoic acid
CAS号 : 53251-94-8
货号 : A217245
分子式 : C26H41Br2NO4
纯度 : 98%
分子量 : 591.416
MDL号 : MFCD01713435
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(84.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(16.91 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
靶点

  • Calcium Channel
描述 Pinaverium bromide acts as a calcium channel blocker in helping to restore the normal contraction process of the bowel.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01641224 Irritable Bowel Syndrome Not Applicable Unknown May 2014 China, Jiangsu ... 展开 >> Second Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210017 Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210029 China Beijing Xuanwu Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Beijing, China, 100050 Shanghai First People's Hospital affiliated to Shanghai Tiao Tong University Shanghai, China, 200240 收起 <<
NCT02330029 Irritable Bowel Syndrome Not Applicable Unknown May 2017 China, Jiangsu ... 展开 >> Second Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210017 Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210029 China Beijing Xuanwu Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Beijing, China, 100050 Shanghai First People's Hospital affiliated to Shanghai Tiao Tong University Shanghai, China, 200240 收起 <<
NCT01678781 - Completed - China ... 展开 >> Site reference ID/Investigator# 94519 Beijing, China, 100034 Site reference ID/Investigator# 95475 Guangzhou City, China, 510515 Site reference ID/Investigator# 94521 Guangzhou, China, 510080 Site reference ID/Investigator # 94518 Shanghai, China, 200127 Site reference ID/Investigator # 94517 Shanghai, China, 200433 Site reference ID/Investigator # 94516 Shanghai, China Site reference ID/Investigator # 94515 Wuhan, China, 430022 Egypt Site Reference ID/Investigator# 95908 Alexandria, Egypt Site reference ID/Investigator# 95900 Cairo, Egypt Site reference ID/Investigator# 95901 El Sharkya, Egypt Site reference ID/Investigator# 95902 Giza, Egypt Site reference ID/Investigator# 95903 Giza, Egypt Site Reference ID/Investigator# 95906 Port Said, Egypt Mexico Site reference ID/Investigaot# 94525 Guadalajara, Mexico, 49000 Site refernce ID/Investigator# 94527 Mexico City, Mexico, 54055 Site reference ID/Investigator# 94523 Tampico, Mexico, 89190 Poland Site reference ID/Investigator# 85314 Bialystok, Poland, 15-270 Site Reference ID/Investigator# 85297 Bialystok, Poland, 15-351 Site Reference ID/Investigator# 85298 Bydgoszcz, Poland, 85-079 Site Reference ID/Investigator# 85293 Katowice, Poland, 40-031 Site Reference ID/Investigator# 85296 Lodz, Poland, 91-473 Site reference ID/Investigator# 85313 Olsztyn, Poland, 10-501 Site Reference ID/Investigator# 85295 Poznan, Poland, 60-193 Site Reference ID/Investigator# 85294 Poznan, Poland, 60-539 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.45mL

1.69mL

0.85mL

16.91mL

3.38mL

1.69mL
参考文献

[1]Dai Y, Liu JX, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61.

[2]Boyer JC, Magous R, et al. Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide. Cell Calcium. 2001 Jun;29(6):429-38.