Ned 19是一种选择性的 NAADP 拮抗剂,具有膜透性,能够以非竞争性机制抑制 NAADP 介导的 Ca2+ 信号通路,IC50 为 65 nM。Ned 19 强烈抑制肿瘤生长、血管生成和肺转移,在抗癌领域具有广泛应用前景。
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产品名称 | Ca2+ channel-like protein ↓ ↑ | Calcium Channel ↓ ↑ | Cav 2.2 ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CDC25B-IN-2 | ✔ | Akt | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Clevidipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Verapamil HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Amlodipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Amlodipine maleate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
(+)-cis-Diltiazem HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Zegocractin |
++
Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Tanshinone IIA sulfonate sodium | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Ulixacaltamide |
++
hCaV3.1, IC50: 50 nM hCaV3.2, IC50: 110 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Dronedarone Hydrochloride | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nitrendipine |
+
Calcium channel, IC50: 95 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Efonidipine HCl monoethanolate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Cinnarizine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SEA0400 |
++
NCX, IC50: 33 nM |
p38 MAPK,ROS,ERK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Fasudil HCl | ✔ | Rho,PKA | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
ML-9 | ✔ | MLCK,Akt | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Flunarizine 2HCl |
+
Calcium channel, Ki: 68 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Lomerizine 2HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Efonidipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Levamlodipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nisoldipine |
++
L-type Cav1.2, IC50: 10 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Isradipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Lacidipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Lercanidipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Loureirin B | ✔ | Potassium Channel | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Tetracaine HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Manidipine |
+++
Calcium channel, IC50: 2.6 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Manidipine Dihydrochlorid |
+++
Calcium channel, IC50: 2.6 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nicardipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Wilforgine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Econazole | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Ginsenoside Rd | ✔ | NF-κB | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Fendiline HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Mesaconitine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Tetrandrine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nifedipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nilvadipine |
++++
Calcium channel, IC50: 0.03 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Barnidipine |
++++
[3H]nitrendipine, Ki: 0.21 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Azelnidipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Levetiracetam | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nimodipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Benidipine HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Pinaverium bromide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Pranidipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
NP118809 |
+
L-type calcium channel, IC50: 12.2 μM N-type Ca2+ channel, IC50: 0.11 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Amlodipine Besylate |
+++
Calcium channel, IC50: 1.9 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Cilnidipine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Cinepazide Maleate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Terfenadine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
YM-58483 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Ranolazine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Praeruptorin A | ✔ | p38 MAPK,Akt | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Ranolazine 2HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Felodipine |
++++
L-type calcium channel, IC50: 0.15 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
PD173212 |
+++
N-type Ca2+ channel, IC50: 36 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Levamlodipine besylate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Carboxyamidotriazole Orotate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
IGS-1.76 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
WH-4-023 |
++++
Cav 2.2, IC50: 0.001 μM |
++++
Cav 2.2, IC50: 0.001 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Ned 19 is a selective, membrane-permeable, non-competitive NAADP antagonist that inhibits NAADP-mediated Ca2+ signalling with an IC50 value of 65 nM[1] .Ned 19 strongly inhibits tumour growth, angiogenesis and lung metastasis in mice.Ned 19 acts in the concentration range of 25-100 μM for 24-72 hours, decreases the percentage of B16 cells in S phase, increases the percentage in G0/G1 phase, induces apoptosis in a concentration- and time-dependent manner, and reduces cell proliferation.Ned 19 decreases N-adhesin expression and increases E-adhesin expression and affects cell migration behaviour[2]. |
Animal study | Administered at a dose of 5 mg/kg/every other day, intraperitoneally for 4 weeks, Ned 19 significantly inhibited tumour growth in a mouse model[2] . |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.94mL 0.39mL 0.19mL |
9.72mL 1.94mL 0.97mL |
19.43mL 3.89mL 1.94mL |
CAS号 | 874374-25-1 |
分子式 | C30H31FN4O3 |
分子量 | 514.591 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 120 mg/mL(233.2 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |