GV-58
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货号：A174625
GV-58 是一种强效选择性的 N 型和 P/Q 型 Ca2+ 通道激动剂，对于 N 型/P-Q 型 Ca2+ 通道的 EC50 分别为 7.21/8.81 μM，其 CDK 抑制活性低于 20 倍。
GV-58 化学结构
GV-58 3D分子结构
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GV-58 纯度/质量文件 产品仅供科研
货号：A174625
标准纯度：
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产品说明书
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GV-58 质控信息
CDC25B-IN-2
✔
Akt
99%+
Clevidipine
✔
97%
Verapamil HCl
✔
99%
Amlodipine
✔
99%
Amlodipine maleate
✔
98%
(+)-cis-Diltiazem HCl
✔
95%
Zegocractin
++
Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM
99%+
Tanshinone IIA sulfonate sodium
✔
98%
Ulixacaltamide
++
hCaV3.1, IC50: 50 nM
hCaV3.2, IC50: 110 nM
99%+
Dronedarone Hydrochloride
✔
95%
Nitrendipine
+
Calcium channel, IC50: 95 nM
98%
Efonidipine HCl monoethanolate
✔
98%
Cinnarizine
✔
98%
SEA0400
++
p38 MAPK,ROS,ERK
99%+
Fasudil HCl
✔
PKA,Rho
98%
ML-9
✔
Akt,MLCK
99%+
Flunarizine 2HCl
+
Calcium channel, Ki: 68 nM
95%
Lomerizine 2HCl
✔
98%
Efonidipine
✔
98%
Levamlodipine
✔
97%
Nisoldipine
++
L-type Cav1.2, IC50: 10 nM
97%
Isradipine
✔
98%
Lacidipine
✔
98%
Lercanidipine
✔
98%
Loureirin B
✔
Potassium Channel
99%+
Tetracaine HCl
✔
98%
Manidipine
+++
Calcium channel, IC50: 2.6 nM
98%
Manidipine Dihydrochlorid
+++
Calcium channel, IC50: 2.6 nM
98%
Nicardipine
✔
98%
Wilforgine
✔
98+%
Econazole
✔
99%+
Ginsenoside Rd
✔
NF-κB
98%
Fendiline HCl
✔
98+%
Mesaconitine
✔
98%
Tetrandrine
✔
95%
Nifedipine
✔
95%
Nilvadipine
++++
Calcium channel, IC50: 0.03 nM
98%
Barnidipine
++++
[3 H]nitrendipine, Ki: 0.21 nM
95+%
Azelnidipine
✔
97%
Levetiracetam
✔
98%
Nimodipine
✔
95%
Benidipine HCl
✔
98%
Pinaverium bromide
✔
98%
Pranidipine
✔
98%
NP118809
+
L-type calcium channel, IC50: 12.2 μM
N-type Ca2+ channel, IC50: 0.11 μM
98%
Amlodipine Besylate
+++
Calcium channel, IC50: 1.9 nM
97%
Cilnidipine
✔
98%
Cinepazide Maleate
✔
98%
Terfenadine
✔
98%
YM-58483
✔
99%+
Ranolazine
✔
98%
Praeruptorin A
✔
Akt,p38 MAPK
98%
Ranolazine 2HCl
✔
98%
Felodipine
++++
L-type calcium channel, IC50: 0.15 nM
98%
PD173212
+++
N-type Ca2+ channel, IC50: 36 nM
98%
Levamlodipine besylate
✔
97%
Carboxyamidotriazole Orotate
✔
98%
IGS-1.76
✔
98+%
WH-4-023
++++
++++
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
GV-58 生物活性
描述
GV-58, a new agonist for N- and P/Q-type calcium (Ca2+ ) channels, has EC50 values of 7.21 and 8.81 μM, respectively. It decelerates channel deactivation, leading to significantly enhanced presynaptic Ca2+ influx upon activation. GV-58 is applicable in research on Lambert-Eaton myasthenic syndrome (LEMS)[1] [2] [3]
体外研究
GV-58 (50 μM; 30 min) reinstates functionality at the neuromuscular junction in a Lambert-Eaton myasthenic syndrome (LEMS) passive transfer model[1]
GV-58 参考文献
GV-58 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.67mL
0.53mL
0.27mL
13.35mL
2.67mL
1.34mL
26.70mL
5.34mL
2.67mL
GV-58 技术信息
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