GV-58

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Chemical Structure| 1402821-41-3 同义名 : -
CAS号 : 1402821-41-3
货号 : A174625
分子式 : C18H26N6OS
纯度 : 99%+
分子量 : 374.504
MDL号 : MFCD28385865
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 80 mg/mL(213.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GV-58, a new agonist for N- and P/Q-type calcium (Ca2+) channels, has EC50 values of 7.21 and 8.81 μM, respectively. It decelerates channel deactivation, leading to significantly enhanced presynaptic Ca2+ influx upon activation. GV-58 is applicable in research on Lambert-Eaton myasthenic syndrome (LEMS)[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.35mL

2.67mL

1.34mL

26.70mL

5.34mL

2.67mL
参考文献

[1]Tarr TB, et al. Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome. J Neurosci. 2013 Jun 19;33(25):10559-67.

[2]Tarr TB, et al. Complete reversal of Lambert-Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist. J Physiol. 2014 Aug 15;592(16):3687-96.

[3]Meriney SD, et al. Lambert-Eaton myasthenic syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads. Ann N Y Acad Sci. 2018 Jan;1412(1):73-81.