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/ Fraxinellone

Fraxinellone {[allProObj[0].p_purity_real_show]}

货号：A145557

Fraxinellone是一种从厚皮橙（Dictamnus dasycarpus Turcz.）树皮中分离的天然产物，具有神经保护、血管松弛、杀虫和抗菌活性，选择性阻断电压依赖性 Ca2+ 通道，同时 dictamine 通过抑制 Ca2+ 流入，松弛大鼠主动脉，可以显著诱导激活的外周 CD4(+) T 细胞的凋亡，从而减少 CD4(+) T 细胞的激活和浸润到肝脏。

Fraxinellone 化学结构 CAS号：28808-62-0
Fraxinellone 化学结构
CAS号：28808-62-0
Fraxinellone 3D分子结构
CAS号：28808-62-0
Fraxinellone 化学结构 CAS号：28808-62-0
Fraxinellone 3D分子结构 CAS号：28808-62-0
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Fraxinellone 纯度/质量文件 产品仅供科研

货号：A145557 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 99%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.1, IC50: 50 nM

hCaV3.2, IC50: 110 nM

 		99%+
Dronedarone Hydrochloride ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ERK,p38 MAPK,ROS 99%+
Fasudil HCl ✔ PKA,Rho 98%
ML-9 ✔ Akt,MLCK 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 98%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 99%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		99%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 99%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 99%
NP118809 +

L-type calcium channel, IC50: 12.2 μM

N-type Ca2+ channel, IC50: 0.11 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 99%
Cinepazide Maleate ✔ 99% (HPLC)
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ Akt,p38 MAPK 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Fraxinellone 生物活性

描述 Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities. Fraxinellone, in a dose-dependented manner, inhibited the expression of programmed cell death ligand-1 (PD-L1), which plays a pivotal role in tumorigenesis[3]. Fraxinellone attenuated the clinical and histologic features of inflammatory arthritis in CIA (collagen-induced arthritis) mice. Fraxinellone alleviated synovial inflammation and osteoclastogenesis in mice[4]. Intraperitoneal injection of fraxinellone significantly inhibited the pancreatic activation of multiple inflammasome molecules such as NACHT, LRR and PYD domains-containing protein 3 (NLRP3), PY-CARD, caspase-1, IL-18, and IL-1β during AP. In addition, fraxinellone treatment inhibited pancreatic injury, elevation in serum amylase and lipase activities, and infiltration of inflammatory cells such as neutrophils and macrophages but had no effect on pancreatic edema[5]. Moreover, fraxinellone administration caused growth arrest and certainly repressed the activity of senescence associated β-galactosidase as well as the expression of senescence-associated-genes[6].

Fraxinellone 参考文献

[1]Wu XF, Ouyang ZJ, et al. Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone. Toxicol Appl Pharmacol. 2014 Nov 15;281(1):146-56.

[2]Lv M, Wu W, Liu H. Insecticidal and feeding deterrent effects of fraxinellone from Dictamnus dasycarpus against four major pests. Molecules. 2013 Mar 1;18(3):2754-62.

[3]Xing Y, Mi C, Wang Z, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018;135:166-180

[4]Jung SM, Lee J, Baek SY, et al. Fraxinellone Attenuates Rheumatoid Inflammation in Mice. Int J Mol Sci. 2018;19(3):829.

[5]Kim MJ, Bae GS, Jo IJ, et al. Fraxinellone inhibits inflammatory cell infiltration during acute pancreatitis by suppressing inflammasome activation. Int Immunopharmacol. 2019;69:169-177

[6]Han X, Chen H, Zhou J, et al. The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. J Cell Physiol. 2018;233(5):3945-3954

Fraxinellone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.31mL

0.86mL

0.43mL

21.53mL

4.31mL

2.15mL

43.05mL

8.61mL

4.31mL

Fraxinellone 技术信息

CAS号28808-62-0
分子式C14H16O3
分子量 232.275
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 105 mg/mL(452.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Fraxinellone | 28808-62-0 | PD-1/PD-L1 | HIF/HIF Prolyl-Hydroxylase | STAT Inhibitor | Immunology/Inflammation | Metabolic Enzyme/Protease | Stem Cell/Wnt | JAK/STAT Signaling | PD-1/PD-L1 | HIF/HIF Prolyl-Hydroxylase | STAT | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Fraxinellone 纯度/质量文件 | Fraxinellone 亚型比较 | Fraxinellone 生物活性 | Fraxinellone 参考文献 | Fraxinellone 实验方案 | Fraxinellone 技术信息

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