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Fraxinellone

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Chemical Structure| 28808-62-0 同义名 : -
CAS号 : 28808-62-0
货号 : A145557
分子式 : C14H16O3
纯度 : 99%
分子量 : 232.275
MDL号 : MFCD11101451
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(452.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities. Fraxinellone, in a dose-dependented manner, inhibited the expression of programmed cell death ligand-1 (PD-L1), which plays a pivotal role in tumorigenesis[3]. Fraxinellone attenuated the clinical and histologic features of inflammatory arthritis in CIA (collagen-induced arthritis) mice. Fraxinellone alleviated synovial inflammation and osteoclastogenesis in mice[4]. Intraperitoneal injection of fraxinellone significantly inhibited the pancreatic activation of multiple inflammasome molecules such as NACHT, LRR and PYD domains-containing protein 3 (NLRP3), PY-CARD, caspase-1, IL-18, and IL-1β during AP. In addition, fraxinellone treatment inhibited pancreatic injury, elevation in serum amylase and lipase activities, and infiltration of inflammatory cells such as neutrophils and macrophages but had no effect on pancreatic edema[5]. Moreover, fraxinellone administration caused growth arrest and certainly repressed the activity of senescence associated β-galactosidase as well as the expression of senescence-associated-genes[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.31mL

0.86mL

0.43mL

21.53mL

4.31mL

2.15mL

43.05mL

8.61mL

4.31mL
参考文献

[1]Wu XF, Ouyang ZJ, et al. Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone. Toxicol Appl Pharmacol. 2014 Nov 15;281(1):146-56.

[2]Lv M, Wu W, Liu H. Insecticidal and feeding deterrent effects of fraxinellone from Dictamnus dasycarpus against four major pests. Molecules. 2013 Mar 1;18(3):2754-62.

[3]Xing Y, Mi C, Wang Z, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018;135:166-180

[4]Jung SM, Lee J, Baek SY, et al. Fraxinellone Attenuates Rheumatoid Inflammation in Mice. Int J Mol Sci. 2018;19(3):829.

[5]Kim MJ, Bae GS, Jo IJ, et al. Fraxinellone inhibits inflammatory cell infiltration during acute pancreatitis by suppressing inflammasome activation. Int Immunopharmacol. 2019;69:169-177

[6]Han X, Chen H, Zhou J, et al. The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. J Cell Physiol. 2018;233(5):3945-3954