Cav 2.2 blocker 1
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货号：A1177068
同义名：
compound 9
Cav 2.2 blocker 1是一种 N 型钙离子通道 (Cav 2.2) 抑制剂，对疼痛研究具有重要应用。
Cav 2.2 blocker 1 化学结构
CAS号：1567335-29-8
Cav 2.2 blocker 1 3D分子结构
CAS号：1567335-29-8
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Cav 2.2 blocker 1 纯度/质量文件 产品仅供科研
货号：A1177068
标准纯度：
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Cav 2.2 blocker 1 质控信息
| CDC25B-IN-2 |
✔
|
|
|
Akt
|
99%+ |
| Clevidipine |
|
✔
|
|
|
97% |
| Verapamil HCl |
|
✔
|
|
|
99% |
| Amlodipine |
|
✔
|
|
|
99% |
| Amlodipine maleate |
|
✔
|
|
|
98% |
| (+)-cis-Diltiazem HCl |
|
✔
|
|
|
95% |
| Zegocractin |
|
++
Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM
|
|
|
99%+ |
| Tanshinone IIA sulfonate sodium |
|
✔
|
|
|
98% |
| Ulixacaltamide |
|
++
hCaV3.1, IC50: 50 nM
hCaV3.2, IC50: 110 nM
|
|
|
99%+ |
| Dronedarone Hydrochloride |
|
✔
|
|
|
95% |
| Nitrendipine |
|
+
Calcium channel, IC50: 95 nM
|
|
|
98% |
| Efonidipine HCl monoethanolate |
|
✔
|
|
|
98% |
| Cinnarizine |
|
✔
|
|
|
98% |
| SEA0400 |
|
++
|
|
ERK,ROS,p38 MAPK
|
99%+ |
| Fasudil HCl |
|
✔
|
|
PKA,Rho
|
98% |
| ML-9 |
|
✔
|
|
Akt,MLCK
|
99%+ |
| Flunarizine 2HCl |
|
+
Calcium channel, Ki: 68 nM
|
|
|
95% |
| Lomerizine 2HCl |
|
✔
|
|
|
98% |
| Efonidipine |
|
✔
|
|
|
98% |
| Levamlodipine |
|
✔
|
|
|
97% |
| Nisoldipine |
|
++
L-type Cav1.2, IC50: 10 nM
|
|
|
97% |
| Isradipine |
|
✔
|
|
|
98% |
| Lacidipine |
|
✔
|
|
|
98% |
| Lercanidipine |
|
✔
|
|
|
98% |
| Loureirin B |
|
✔
|
|
Potassium Channel
|
99%+ |
| Tetracaine HCl |
|
✔
|
|
|
98% |
| Manidipine |
|
+++
Calcium channel, IC50: 2.6 nM
|
|
|
98% |
| Manidipine Dihydrochlorid |
|
+++
Calcium channel, IC50: 2.6 nM
|
|
|
98% |
| Nicardipine |
|
✔
|
|
|
98% |
| Wilforgine |
|
✔
|
|
|
98+% |
| Econazole |
|
✔
|
|
|
99%+ |
| Ginsenoside Rd |
|
✔
|
|
NF-κB
|
98% |
| Fendiline HCl |
|
✔
|
|
|
98+% |
| Mesaconitine |
|
✔
|
|
|
98% |
| Tetrandrine |
|
✔
|
|
|
95% |
| Nifedipine |
|
✔
|
|
|
95% |
| Nilvadipine |
|
++++
Calcium channel, IC50: 0.03 nM
|
|
|
98% |
| Barnidipine |
|
++++
[3H]nitrendipine, Ki: 0.21 nM
|
|
|
95+% |
| Azelnidipine |
|
✔
|
|
|
97% |
| Levetiracetam |
|
✔
|
|
|
98% |
| Nimodipine |
|
✔
|
|
|
95% |
| Benidipine HCl |
|
✔
|
|
|
98% |
| Pinaverium bromide |
|
✔
|
|
|
98% |
| Pranidipine |
|
✔
|
|
|
98% |
| NP118809 |
|
+
N-type Ca2+ channel, IC50: 0.11 μM
L-type calcium channel, IC50: 12.2 μM
|
|
|
98% |
| Amlodipine Besylate |
|
+++
Calcium channel, IC50: 1.9 nM
|
|
|
97% |
| Cilnidipine |
|
✔
|
|
|
98% |
| Cinepazide Maleate |
|
✔
|
|
|
98% |
| Terfenadine |
|
✔
|
|
|
98% |
| YM-58483 |
|
✔
|
|
|
99%+ |
| Ranolazine |
|
✔
|
|
|
98% |
| Praeruptorin A |
|
✔
|
|
Akt,p38 MAPK
|
98% |
| Ranolazine 2HCl |
|
✔
|
|
|
98% |
| Felodipine |
|
++++
L-type calcium channel, IC50: 0.15 nM
|
|
|
98% |
| PD173212 |
|
+++
N-type Ca2+ channel, IC50: 36 nM
|
|
|
98% |
| Levamlodipine besylate |
|
✔
|
|
|
97% |
| Carboxyamidotriazole Orotate |
|
✔
|
|
|
98% |
| IGS-1.76 |
|
✔
|
|
|
98+% |
| WH-4-023 |
|
++++
|
++++
|
|
99%+ |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
|
Cav 2.2 blocker 1 生物活性
| 描述 |
Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2) blocker for the treatment of pain with an IC50 of 1 nM[1]. |
Cav 2.2 blocker 1 参考文献
Cav 2.2 blocker 1 实验方案
| 计算器 |
|
| 存储液制备 |
 |
1mg |
5mg |
10mg |
|
1 mM
5 mM
10 mM
|
2.35mL
0.47mL
0.24mL
|
11.77mL
2.35mL
1.18mL
|
23.53mL
4.71mL
2.35mL
|
Cav 2.2 blocker 1 技术信息
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