Tacrolimus (FK506) 是一种大环内酯，结合 FK506 结合蛋白 (FKBP) 形成复合物，抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号传导和 IL-2 转录，具有免疫抑制特性。

Oxaprozin is a COX inhibitor with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, it's a NSAID used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases.

NS-398是一种非甾体抗炎剂，具有镇痛和退热作用。它选择性抑制前列腺素G/H合酶2/环氧合酶2（COX-2）的活性，IC50值为3.8 μM，而对COX-1在100 μM时没有影响。

Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.

Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders.