(±)-10-Hydroxycamptothecin is an inhibitor oftopoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate.
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10-Hydroxycamptothecin (HCPT) is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate. Gel electrophoresis found that HCPT had a selectively inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on the other kinds of histones. In vivo, HCPT also exhibited a suppressive effect on histone H1 and H3 phosphorylation[1]. After treatment with HCPT at differentiation-inducing concentrations 5-20 mg/L for 6 d, Hep G2 cells were mainly arrested at G2/M phase and the PCNA expression rate was lower than that of control cells. When Hep G2 cells grew in a medium containing HCPT 5 mg/L for 6 d, the p53 expression level markedly increased in comparison with the control cells. The telomerase activity did not change in Hep G2 cells treated with HCPT 5-20 mg/L for 8 d[2]. HCPT exhibited adverse effects on mouse oocyte maturation and quality, and MT (Melatonin) administration alleviated the negative influence of HCPT[3].
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