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alpha-Cyperone
α-香附酮 /alpha-Cyperone
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货号：A253603
同义名：
(+)-α-Cyperone;α-Cyperone
alpha-Cyperone 是一种天然产物，从 Cyperus rotundus L. 的根茎中分离纯化，能下调 COX-2、IL-6、Nck-2、Cdc42 和 Rac1，从而减少炎症反应。
alpha-Cyperone 化学结构
alpha-Cyperone 3D分子结构
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alpha-Cyperone 纯度/质量文件 产品仅供科研
货号：A253603
标准纯度：
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产品说明书
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alpha-Cyperone 质控信息
alpha-Cyperone 生物活性
描述
α-Cyperone, extracted from Cyperus rotundus, can inhibit microglia-mediated neuroinflammation. α-cyperone substantially decreased H2O2-induced death, release of LDH, and the production of ROS in SH-SY5Y cells. α-cyperone attenuated H2O2-induced cellular apoptosis. Moreover, α-cyperone remarkably reduced the expression of cleaved-caspase-3 and Bax, and upregulated Bcl-2. Furthermore, α-cyperone enhanced the nuclear translocation of Nrf2[3] [4] [5] [6]
alpha-Cyperone 参考文献
[1] Azimi A, Ghaffari SM, et al. α-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain. J Ethnopharmacol. 2016 Dec 24;194:219-227.
[2] Jung SH, Kim SJ, et al. α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells. J Ethnopharmacol. 2013 May 2;147(1):208-14.
[3] Huang B, Liu J, Fu S, Zhang Y, Li Y, He D, Ran X, Yan X, Du J, Meng T, Gao X, Liu D. α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2. Front Pharmacol. 2020 Apr 8;11:281
[4] Jung SH, Kim SJ, Jun BG, Lee KT, Hong SP, Oh MS, Jang DS, Choi JH. α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inh+ibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells. J Ethnopharmacol. 2013 May 2;147(1):208-14
[5] Zhang H, Li S, Lu J, Jin J, Zhu G, Wang L, Yan Y, He L, Wang B, Wang X, Yu H. α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice. Aging (Albany NY). 2021 Jul 8;13(13):17690-17706
[6] Luo M, Qiu J, Zhang Y, Wang J, Dong J, Li H, Leng B, Zhang Q, Dai X, Niu X, Zhao S, Deng X. α-cyperone alleviates lung cell injury caused by Staphylococcus aureus via attenuation of α-hemolysin expression. J Microbiol Biotechnol. 2012 Aug;22(8):1170-6
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alpha-Cyperone 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
4.58mL
0.92mL
0.46mL
22.90mL
4.58mL
2.29mL
45.80mL
9.16mL
4.58mL
alpha-Cyperone 技术信息
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