alpha-Cyperone
产品说明书
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同义名 : | (+)-α-Cyperone;α-Cyperone |
| CAS号 : | 473-08-5 | |
| 货号 : | A253603 | |
| 分子式 : | C15H22O | |
| 纯度 : | 95% | |
| 分子量 : | 218.335 | |
| MDL号 : | MFCD09839027 | |
| 存储条件： |
Pure form Sealed in dry,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(480.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 150 mg/mL(687.02 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | α-Cyperone, extracted from Cyperus rotundus, can inhibit microglia-mediated neuroinflammation. α-cyperone substantially decreased H2O2-induced death, release of LDH, and the production of ROS in SH-SY5Y cells. α-cyperone attenuated H2O2-induced cellular apoptosis. Moreover, α-cyperone remarkably reduced the expression of cleaved-caspase-3 and Bax, and upregulated Bcl-2. Furthermore, α-cyperone enhanced the nuclear translocation of Nrf2[3]. The anti-inflammatory activity of α-cyperone is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells[4]. In addition, in vivo studies based on a mouse model of arthritis showed that α-Cyperone prevented the development of osteoarthritis[5]. In addition, α-cyperone is also a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.58mL 0.92mL 0.46mL |
22.90mL 4.58mL 2.29mL |
45.80mL 9.16mL 4.58mL |
| 参考文献 |
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