There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Valrubicin (AD 32) is a chemotherapy agent that inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively. Valrubicin competes with the tumor promoter for the PKC binding site, preventing its interaction with phospholipids and binding to PKC [1]. Valrubicin exhibits cytotoxicity against squamous cell carcinoma (SCC) cell line colony formation, with IC50s and IC90s of 8.24 ± 1.60 μM and 14.81 ± 2.82 μM for UMSCC5 cells, 15.90 ± 0.90 μM and 29.84 ± 0.84 μM for UMSCC5/CDDP‡ cells, and 10.50 ± 2.39 μM and 19.00 ± 3.91 μM for UMSCC10b cells, respectively. Additionally, the combination of Valrubicin with radiation enhances cytotoxicity [2].
体内研究
Valrubicin, administered via intratumoral injection at doses of 3, 6, or 9 mg, decreases tumor growth by week 3 in hamsters. Combining Valrubicin at a dose of 6 mg with minimally cytotoxic irradiation (150, 250, or 350 cGy) induces substantial tumor shrinkage in hamsters [2].
Valrubicin (0.1 μg/μL) markedly reduces the infiltration of neutrophils in TPA-challenged biopsies after 24 hours and mitigates chronic inflammation in mice. Additionally, Valrubicin lowers the expression levels of inflammatory cytokines in the acute model [3].
体外研究
Valrubicin (AD 32) is a chemotherapy agent that inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively. Valrubicin competes with the tumor promoter for the PKC binding site, preventing its interaction with phospholipids and binding to PKC [1].
Valrubicin exhibits cytotoxicity against squamous cell carcinoma (SCC) cell line colony formation, with IC50s and IC90s of 8.24 ± 1.60 μM and 14.81 ± 2.82 μM for UMSCC5 cells, 15.90 ± 0.90 μM and 29.84 ± 0.84 μM for UMSCC5/CDDP‡ cells, and 10.50 ± 2.39 μM and 19.00 ± 3.91 μM for UMSCC10b cells, respectively. Additionally, the combination of Valrubicin with radiation enhances cytotoxicity [2].
Withdrawn(The Investigator-Coo... 展开 >>rdinator has moved to Rennes University Hospital. It will be done under the sponsor of Rennes University Hospital NCT03686306) 收起 <<
United States, Florida
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H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612-9497
United States, Illinois
CCOP - Carle Cancer Center
Urbana, Illinois, United States, 61801
United States, New Jersey
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, United States, 07018-1095
United States, Pennsylvania
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
CCOP - MainLine Health
Wynnewood, Pennsylvania, United States, 19096
United States, Wisconsin
CCOP - Green Bay
Green Bay, Wisconsin, United States, 54301
Veterans Affairs Medical Center - Madison
Madison, Wisconsin, United States, 53705
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States, 53792-6164
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Veterans Affairs Medical Center - Milwaukee (Zablocki)
Milwaukee, Wisconsin, United States, 53295 收起 <<
United States, Arizona
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BCG Oncology
Phoenix, Arizona, United States, 85032
United States, Florida
Urology Research Network
Hialeah, Florida, United States, 33149
Advanced Urology Association of Florida
Vero Beach, Florida, United States, 32960
United States, Kansas
Kansas City Urology Care
Overland Park, Kansas, United States, 66211
United States, New Jersey
Delaware Valley Urology
Sewell, New Jersey, United States, 08080
Delaware Valley Urology
Voorhees, New Jersey, United States, 08043
United States, New York
Long Island Urological Associates
Bethpage, New York, United States, 11714
United States, Pennsylvania
Urologic Consultants of SE PA
Bala-Cynwyd, Pennsylvania, United States, 19004
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
United States, Texas
Urology Associates of North Texas
Arlington, Texas, United States, 76017
Urology Clinics of North Texas
Dallas, Texas, United States, 75231 收起 <<
United States, Arizona
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BCG Oncology
Phoenix, Arizona, United States, 85032-2129
United States, California
University of California, San Diego- Moores Cancer Center
La Jolla, California, United States, 92093
UCLA Institute of Urological Oncology
Los Angeles, California, United States, 90024
University of California, Davis- Cancer Center
Sacramento, California, United States, 95817
United States, Illinois
University of Chicago, Department of Surgery, Section of Urology
Chicago, Illinois, United States, 60637
United States, North Carolina
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
United States, Tennessee
Vanderbilt University Medical Center Department of Urologic Surgery
Nashville, Tennessee, United States, 37232 收起 <<
Carcinoma in Situ
... 展开 >> Transitional Cell Carcinoma
Non-muscle Invasive Bladder Cancer 收起 <<
Phase 3
Terminated
-
United States, Arizona
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BCG Oncology
Phoenix, Arizona, United States, 85032
United States, Colorado
The Urology Center of Colorado
Denver, Colorado, United States, 80211
United States, Maryland
Urology Associates
Cumberland, Maryland, United States, 21502
United States, New Jersey
Delaware Valley Urology
Sewell, New Jersey, United States, 08080
United States, New York
Associated Medical Professionals of New York
Syracuse, New York, United States, 13210
United States, Pennsylvania
Urologic Consultants of SE PA
Bala-Cynwyd, Pennsylvania, United States, 19004 收起 <<
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