产品说明书

Ofloxacin

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Chemical Structure| 82419-36-1 同义名 : 菲宁达 ;Hoe-280;DL8280
CAS号 : 82419-36-1
货号 : A510593
分子式 : C18H20FN3O4
纯度 : 98+%
分子量 : 361.37
MDL号 : MFCD00226105
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(8.3 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Topo II
描述 Ofloxacin (Hoe-280) is a fluoroquinolone antibiotic primarily acting through the inhibition of bacterial DNA gyrase. It exhibits a broad spectrum of activity against aerobic Gram-negative and Gram-positive bacteria in vitro, but shows limited efficacy against anaerobes[1]. Unlike many other front-line antibacterial drugs that target cell wall or protein synthesis, ofloxacin and other 4-quinolones uniquely interfere with bacterial DNA synthesis, distinguishing their mechanism of action in treating bacterial infections[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02711943 - Completed - -
NCT00720980 - Completed - United States, Michigan ... 展开 >> Henry Ford Medical Center Detroit, Michigan, United States, 48202 收起 <<
NCT00210886 Urinary Tract Infections ... 展开 >> Pyelonephritis 收起 << Phase 3 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.84mL

2.77mL

1.38mL

27.67mL

5.53mL

2.77mL
参考文献

[1]Todd PA, et al. Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use. Drugs. 1991 Nov;42(5):825-76.

[2]Smith JT, et al. Ofloxacin, a bactericidal antibacterial. Chemotherapy. 1991;37 Suppl 1:2-13.

[3]Olcay E, et al. Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin: comparison of biomechanical and histopathological effects on Achilles tendon in rats. J Toxicol Sci. 2011 Jun;36(3):339-45.