Norfloxacin|MK-0366|氟哌酸|Drug Standard|Quinolone|Topoisomerase|Antibacterial|for research only|Ambeed

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诺氟沙星 /Norfloxacin {[allProObj[0].p_purity_real_show]}

货号：A165613 同义名： 氟哌酸 / MK-0366

Norfloxacin inhibits DNA gyrase and is used as a broad-spectrum antibiotic against both Gram-positive and Gram-negative bacteria.

Norfloxacin 化学结构
CAS号：70458-96-7

Norfloxacin 3D分子结构
CAS号：70458-96-7

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Norfloxacin 纯度/质量文件产品仅供科研

货号：A165613 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

拓扑异构酶亚型比较

产品名称	Topo I ↓ ↑	Topo II ↓ ↑	Topo IV ↓ ↑	Topoisomerase ↓ ↑	其他靶点	纯度
Ellagic acid	✔					98%
β-Lapachone	✔					99%+
(s)-10-hydroxycamptothecin	✔					98+%
Camptothecin	++ Topo I, IC50: 0.68 μM					98%
Betulinic acid	++ Eukaryotic topoisomerase I, IC50: 5 μM					98%
Topotecan	++++ Topo I (DU-145 Luc cells), IC50: 2 nM Topo I (MCF-7 Luc cells), IC50: 13 nM					98%
Irinotecan HCl Trihydrate	✔					98%
SN-38	✔					98%
Levofloxacin hydrate		✔				98%
Dexrazoxane		✔				99%+
Ofloxacin		✔				98+%
Enoxacin		✔				99%+
Flumequine		+ Topo II, IC50: 15 μM				98%
Levofloxacin		✔				97%
Etoposide		✔				98%
Pefloxacin mesylate dihydrate		✔				99+%
Marbofloxacin		✔				98+%
Voreloxin HCl		✔				98%
Mitoxantrone dihydrochloride		✔			PKC	98%
Nalidixic acid		✔				98%
Doxorubicin		✔				98%
Novobiocin sodium		✔				95%
Amonafide		✔				99%+
Pirarubicin		✔				98%+
Idarubicin HCl		+++ Topo II (MCF-7 cells), IC50: 3.3 ng/mL				99%+
Genistein		✔			EGFR	98%
Teniposide		✔				98%
Moxifloxacin		✔				98%
Ciprofloxacin			✔			98%
Clinafloxacin			✔			97%
Gatifloxacin				✔		98%
Daunorubicin HCl				+++ DNA synthesis, Ki: 20 nM		98%
Epirubicin HCl				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Norfloxacin 生物活性

描述	Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

Norfloxacin 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01508507	-		Unknown	March 2014	India ... 展开 >> Regional Medical Research Center Recruiting Chandrashekharpur, Bhubaneswar, Odisha, India, 751016 Contact: Shantanu K Kar, MD 91-674-301322 rmrcdir@sancharnet.in Contact: Anna S Kerketta, MBBS 91-674-2301387 solani_bara@rediffmail.com Sub-Investigator: Hemant K Khuntia, MBBS 收起 <<
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD 收起 <<
NCT00701792	Cirrhosis	Not Applicable	Completed	-	France ... 展开 >> service d'hépatologie CHU jean Minjoz Besancon, France, 25000 CHRU CAEN - Service d'hépato-gastroentérologie Caen, France, 14033 Hôpital Beaujon - Hépato-gastroentérologie Clichy, France, 92110 CHU Henri Mondor - Hépato-gastroentérologie Creteil, France, 94010 Hépato-gastroenterologie CHU Bocage Dijon, France, 21034 Centre d'épidémiologie de population EPI 106 Dijon, France, 21079 Hôpital Bon secours - Hépato-gastroentérologie Metz, France, 57000 Hôpital Saint-Eloi - Hépato-gastroentérologie Montpellier, France, 34295 Hôpital Pitié-Salpétrière - Hépato-gastroentérologie Paris, France, 75013 Hepato-gastroenterologie Poitiers, France, 86021 CHU Reims - hépato-gestroentérologie Reims, France, 51092 Clinique des maladies du foie Hôpital Pontchailloux Rennes, France, 35000 Hôpital Purpan - Hépato-gastroentérologie Toulouse, France, 31059 收起 <<

Norfloxacin 参考文献

[1]Dong J, Ruan J, et al. In vitro synergistic effects of fisetin and norfloxacin against aquatic isolates of Serratia marcescens. FEMS Microbiol Lett. 2016 Jan;363(1):fnv220.

[2]Gadebusch HH, Shungu DL, et al. Comparison of the antibacterial activity of norfloxacin (MK 0366, AM 715), a new organic acid, with that of other orally absorbed chemotherapeutic agents. Infection. 1982 Jan;10(1):41-4.

Norfloxacin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.13mL

0.63mL

0.31mL

15.66mL

3.13mL

1.57mL

31.32mL

6.26mL

3.13mL

Norfloxacin 技术信息

CAS号	70458-96-7
分子式	C₁₆H₁₈FN₃O₃
分子量	319.331

别名	氟哌酸 ;MK-0366
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature

溶解度

DMSO: 4 mg/mL(12.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01508507	-		Unknown	March 2014	India ... 展开 >> Regional Medical Research Center Recruiting Chandrashekharpur, Bhubaneswar, Odisha, India, 751016 Contact: Shantanu K Kar, MD 91-674-301322 rmrcdir@sancharnet.in Contact: Anna S Kerketta, MBBS 91-674-2301387 solani_bara@rediffmail.com Sub-Investigator: Hemant K Khuntia, MBBS 收起 <<
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD 收起 <<
NCT00701792	Cirrhosis	Not Applicable	Completed	-	France ... 展开 >> service d'hépatologie CHU jean Minjoz Besancon, France, 25000 CHRU CAEN - Service d'hépato-gastroentérologie Caen, France, 14033 Hôpital Beaujon - Hépato-gastroentérologie Clichy, France, 92110 CHU Henri Mondor - Hépato-gastroentérologie Creteil, France, 94010 Hépato-gastroenterologie CHU Bocage Dijon, France, 21034 Centre d'épidémiologie de population EPI 106 Dijon, France, 21079 Hôpital Bon secours - Hépato-gastroentérologie Metz, France, 57000 Hôpital Saint-Eloi - Hépato-gastroentérologie Montpellier, France, 34295 Hôpital Pitié-Salpétrière - Hépato-gastroentérologie Paris, France, 75013 Hepato-gastroenterologie Poitiers, France, 86021 CHU Reims - hépato-gestroentérologie Reims, France, 51092 Clinique des maladies du foie Hôpital Pontchailloux Rennes, France, 35000 Hôpital Purpan - Hépato-gastroentérologie Toulouse, France, 31059 收起 <<
NCT00826670	Enterobacteriaceae Infections	Phase 4	Completed	-	Switzerland ... 展开 >> Geneva Universits Hospitals Geneva, Switzerland, 1211 收起 <<
NCT03627338	-		Not yet recruiting	May 31, 2021	-
NCT02463721	Primary Bacterial Peritonitis	Not Applicable	Recruiting	December 2019	Egypt ... 展开 >> Tanta university hospital Recruiting Tanta, Egypt Contact: Sherief Abd-Elsalam 00201000040794 Sherif_tropical@yahoo.com 收起 <<
NCT01881438	-		Completed	-	-
NCT00678613	Spontaneous Bacterial Peritoni... 展开 >>tis Liver Cirrhosis 收起 <<	Phase 2 Phase 3	Unknown	-	India ... 展开 >> All India Institute of Medical Sciences Recruiting New Delhi, Delhi, India, 110029 Contact: Subrat K Acharya, DM 91-11-2658-8500 ext 4934 subratacharya2004@yahoo.com Contact: Ramesh Kumar, MD 99-6840-7350 drramesh1977@yahoo.com Sub-Investigator: Ramesh Kumar, MD Sub-Investigator: Geeta Satapathy, MD 收起 <<
NCT00163982	Portal Hypertension	Not Applicable	Unknown	-	Australia, Victoria ... 展开 >> Alfred Hospital Recruiting Melbourne, Victoria, Australia, 3181 Contact: William W Kemp, MBBS, FRACP 92762000 ext 3327 w.kemp@alfred.org.au 收起 <<
NCT01134692	Cirrhosis Var... 展开 >>ices, Esophageal 收起 <<	Phase 3	Unknown	-	India ... 展开 >> GB Pant hospital Recruiting Delhi, India, 110002 Contact: Nitin Gupta, MD +919718599209 drnitingupta_id@rediffmail.com 收起 <<
NCT03479736	-		Completed	-	United States, New Jersey ... 展开 >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 收起 <<
NCT00947336	Cirrhosis With Ascites	Phase 3	Completed	-	India ... 展开 >> Department of Gastroenterology, G B Pant Hospital New Delhi, Delhi, India, 110002 收起 <<
NCT01527019	Cystitis	Phase 3	Withdrawn(the company suspende... 展开 >>d the persecution of this combination) 收起 <<	-	-
NCT00359853	Spontaneous Bacterial Peritoni... 展开 >>tis Hepatorenal Syndrome Cirrhosis 收起 <<	Phase 4	Completed	-	Spain ... 展开 >> Hospital Clinic Barcelona Barcelona, Catalonia, Spain, 08036 收起 <<
NCT01039545	Urinary Tract Infections	Phase 4	Terminated(New power calculati... 展开 >>on (reduction of necessary patient number)) 收起 <<	-	Switzerland ... 展开 >> Institute for Infectious Diseases, University of Berne Berne, Switzerland, 3010 收起 <<
NCT01037959	Cirrhosis	Phase 3	Terminated(lack of recruitemen... 展开 >>t) 收起 <<	-	France ... 展开 >> Assisatnce publique Hoptitaux de Paris Clichy, France, 92110 收起 <<
NCT00362752	Hepatopulmonary Syndrome	Phase 2	Completed	-	Canada, Ontario ... 展开 >> St. Michael's Hospital Toronto, Ontario, Canada, M5B 1W8 收起 <<
NCT02120196	Spontaneous Bacterial Peritoni... 展开 >>tis Ascites Liver Cirrhosis 收起 <<	Phase 3	Recruiting	December 2023	Egypt ... 展开 >> Tanta university hospital Recruiting Tanta, Egypt Contact: Sherief Abd-Elsalam 00201000040794 Sherif_tropical@yahoo.com 收起 <<
NCT01542801	Adverse Reaction to Other Drug... 展开 >>s and Medicines 收起 <<	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Korea University Ansan Hospital Ansan, Gyeonggi-do, Korea, Republic of Soonchunhyang University College of Medicine, Bucheon Hospital Bucheon, Korea, Republic of Soonchunhyang University College of Medicine, Cheonan Hospital Cheonan, Korea, Republic of Kyungpuk National University Hospital Daegu, Korea, Republic of Korea University Anam Hospital Seoul, Korea, Republic of Soonchunhyang University College of Medicine, Seoul Hospital Seoul, Korea, Republic of Sungkyunkwan University Gangbuk Samsung Hospital Seoul, Korea, Republic of 收起 <<
NCT03702426	Spontaneous Bacterial Peritoni... 展开 >>tis 收起 <<	Not Applicable	Recruiting	September 30, 2019	India ... 展开 >> Institute of Liver & Biliary Sciences Recruiting New Delhi, Delhi, India, 110070 Contact: Dr Manjul Mishra, MD 01146300000 manjul2883@gmail.com 收起 <<
NCT03506256	Urinary Tract Infections	Phase 4	Not yet recruiting	July 30, 2018	-
NCT03695705	Cirrhosis, Liver	Phase 3	Completed	-	-

诺氟沙星 /Norfloxacin {[allProObj[0].p_purity_real_show]}

Norfloxacin 纯度/质量文件产品仅供科研

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Norfloxacin 参考文献

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Norfloxacin 实验方案

Norfloxacin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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确认信息

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