Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. Topical nadifloxacin is effective, tolerable, and safe for mild or moderate facial acne. Its clinical effectiveness is comparable to clindamycin when used as add-on therapy to benzoyl peroxide[3]. Nadifloxacin has potential as a topical agent for short-term treatment of skin infections[2]. PHMB/nadifloxacin (polymer polyhexamethylene biguanide, PHMB) nanoparticles are effective against intracellular bacteria and could be further developed for the treatment of skin and soft tissue infections[4]. LC-EC cultured with nadifloxacin at 10 microg/ml or more significantly suppressed the antigen-presenting function of LC (Langerhans cells) for T cells. The ability of MHC class II+ keratinocytes to present a superantigen to T cells was suppressed by preincubation of keratinocytes with 30 microg/ml or more of nadifloxacin. Nadifloxacin downmodulates cutaneous immunity by interfering with the antigen-presenting ability of epidermal cells[5].
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