产品说明书
Nadifloxacin
 |
同义名 : | OPC7251 |
| CAS号 : | 124858-35-1 | |
| 货号 : | A140688 | |
| 分子式 : | C19H21FN2O4 | |
| 纯度 : | 98% | |
| 分子量 : | 360.38 | |
| MDL号 : | MFCD00865081 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 25 mg/mL(69.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. Topical nadifloxacin is effective, tolerable, and safe for mild or moderate facial acne. Its clinical effectiveness is comparable to clindamycin when used as add-on therapy to benzoyl peroxide[3]. Nadifloxacin has potential as a topical agent for short-term treatment of skin infections[2]. PHMB/nadifloxacin (polymer polyhexamethylene biguanide, PHMB) nanoparticles are effective against intracellular bacteria and could be further developed for the treatment of skin and soft tissue infections[4]. LC-EC cultured with nadifloxacin at 10 microg/ml or more significantly suppressed the antigen-presenting function of LC (Langerhans cells) for T cells. The ability of MHC class II+ keratinocytes to present a superantigen to T cells was suppressed by preincubation of keratinocytes with 30 microg/ml or more of nadifloxacin. Nadifloxacin downmodulates cutaneous immunity by interfering with the antigen-presenting ability of epidermal cells[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.77mL 0.55mL 0.28mL |
13.87mL 2.77mL 1.39mL |
27.75mL 5.55mL 2.77mL |
| 参考文献 |
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