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Mefenamic Acid

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Chemical Structure| 61-68-7 同义名 : 甲灭酸 ;C.I. 473;CN-35355;Apo Mefenamic;Antigen Brand of Mefenamic Acid;Acid, Mefenaminic;Acid, Mefenamic;Mefacit;Clonmel Brand of Mefenamic Acid;Coslan;Parkemed;Ponstel;NSC 94437;CI 473
CAS号 : 61-68-7
货号 : A138400
分子式 : C15H15NO2
纯度 : 95%
分子量 : 241.285
MDL号 : MFCD00051721
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(435.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • COX-1
描述 Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[2]. Mefenamic acid exerted cytotoxic effects on KB, Saos-2, and 1321N cells, where the viability was approximately 75%. U-87MG cells were resistant to mefenamic acid[3]. Moreover, the memory enhancing activity of mefenamic acid might be due to activation of cholinergic transmission that has protected neuroinflammatory and neurodegenerative conditions caused by alcohol[4]. Mefenamic acid had anti-inflammatory effects but did not reduce the progression of OA (osteoarthritis) lesions, thereby indicating that it is only effective for symptomatic control of OA[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02580344 Contraception Phase 2 Completed - Egypt ... 展开 >> Assiut university Assiut, Egypt, 71111 收起 <<
NCT02968823 Pain, Postoperative ... 展开 >> Surgery, Oral 收起 << Not Applicable Recruiting December 2019 Austria ... 展开 >> MUVienna Recruiting Vienna, Austria Contact: Olga Plattner       olga.plattner@meduniwien.ac.at 收起 <<
NCT02943655 Improve Quality of Life ... 展开 >> Heavy Menstrual Bleeding 收起 << Phase 3 Recruiting February 2019 Egypt ... 展开 >> Ahmed Abbas Recruiting Assiut, Cairo, Egypt, 002 Contact: ahmed abbas       bmr90@hotmail.com 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.14mL

0.83mL

0.41mL

20.72mL

4.14mL

2.07mL

41.44mL

8.29mL

4.14mL
参考文献

[1]Pringsheim T, Davenport WJ, et al. Acute treatment and prevention of menstrually related migraine headache: evidence-based review. Neurology. 2008 Apr 22;70(17):1555-63.

[2]Gierse JK, Hauser SD, Creely DP, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995;305 ( Pt 2)(Pt 2):479-484

[3]Hashemipour MA, Mehrabizadeh Honarmand H, Falsafi F, Tahmasebi Arashlo M, Rajabalian S, Gandjalikhan Nassab SA. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016;17(3):219-225

[4]Rajesh V, Mridhulmohan M, Jayaseelan S, Sivakumar P, Ganesan V. Mefenamic Acid Attenuates Chronic Alcohol Induced Cognitive Impairment in Zebrafish: Possible Role of Cholinergic Pathway. Neurochem Res. 2018;43(7):1392-1404

[5]Aguiar GC, Queiroz-Junior CM, Sitta GL, et al. Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis. Int J Exp Pathol. 2016;97(6):438-446