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Meclofenamic acid sodium

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Chemical Structure| 6385-02-0 同义名 : 甲氯灭酸钠 ;Meclofenamate sodium;Meclofenamate (sodium salt);Meclofenamic Acid;CI 583
CAS号 : 6385-02-0
货号 : A267516
分子式 : C14H10Cl2NNaO2
纯度 : 99%
分子量 : 318.13
MDL号 : MFCD00077376
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(377.2 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(314.34 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • COX-2

    COX-2, IC50:50 nM

  • COX-1

    COX-1, IC50:40 nM
描述 Meclofenamate Sodium (MS) is an nonsteroidal anti-inflammatory drugs (NSAIDs) used to reduce pain. Addition of exogenous proteasome to MS treated cells improved cell viability[2]. Single 100- and 200-mg doses of meclofenamate sodium are as safe as, and significantly more effective than, codeine 60 mg or placebo for episiotomy pain[3]. In the majority of patients (headache and craniofacial pain), the meclofenamate sodium period scored lowest or second-lowest after the follow-up period in mean pain intensity[4]. Meclofenamate sodium in the dose administered was equally effective in relieving pain and inflammation and restoring restricted function in patients with acute gout as indometacin when used in the generally recommended dose for this indication. Meclofenamate sodium, even at these high dosage levels, was better tolerated than indometacin[5]. Similar improvement in mobility of the vertebral column and spondylitic pain could be achieved with meclofenamate sodium and indometacin in patients with ankylosing spondylitis. Meclofenamate sodium offers an effective and safe alternative to indometacin in the treatment of patients with ankylosing spondylitis[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02429570 Recurrent Brain Metastases ... 展开 >> Progressive Brain Metastases 收起 << Not Applicable Active, not recruiting April 2019 United States, Florida ... 展开 >> Baptist Health South Florida Miami, Florida, United States, 33143 United States, New Jersey Memoral Sloan Kettering Cancer Center Basking Ridge, New Jersey, United States Memorial Sloan Kettering Monmouth Middletown, New Jersey, United States, 07748 United States, New York Memorial Sloan Kettering Cancer Center at Commack Commack, New York, United States, 11725 Memorial Sloan Kettering Westchester Harrison, New York, United States, 10604 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Pennsylvania Lehigh Valley Health Network Allentown, Pennsylvania, United States, 18103 收起 <<
NCT02930005 Psychotic Disorders ... 展开 >> Schizophrenia Schizoaffective Disorder Bipolar Disorder 收起 << Phase 2 Enrolling by invitation November 4, 2017 United States, Texas ... 展开 >> Harris County Psychiatric Center Houston, Texas, United States, 77021 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.72mL

3.14mL

1.57mL

31.43mL

6.29mL

3.14mL
参考文献

[1]Eleftheriou CG, Cehajic-Kapetanovic J, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345.

[2]Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol. 2016;94:131-144

[3]Hebertson RM, Storey N, Turner JL. Analgesic efficacy of meclofenamate sodium in episiotomy pain. Pharmacotherapy. 1986;6(5):205-210

[4]Mongini F, Bona G, Garnero M, Gioria A. Efficacy of meclofenamate sodium versus placebo in headache and craniofacial pain. Headache. 1993;33(1):22-28

[5]Eberl R, Dunky A. Meclofenamate sodium in the treatment of acute gout. Results of a double-blind study. Arzneimittelforschung. 1983;33(4A):641-643

[6]Ebner W, Poal Ballarin JM, Boussina I. Meclofenamate sodium in the treatment of ankylosing spondylitis. Report of a European double-blind controlled multicenter study. Arzneimittelforschung.1983;33(4A):660-663