Isosteviol, an antihyperglycemic agent, is a natural product isolated and purified from the herbs of Stevia rebaudiana with anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant properties.
Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana. Isosteviol dose-dependently relaxed the vasopressin (10(-8) M)-induced vasoconstriction in isolated aortic rings with or without endothelium. Vasodilatation induced by isosteviol is related to the opening of SK(Ca) and K(ATP) channels[3]. The increase of [Ca (2+)]i in A7r5 cells produced by vasopressin (1 micromol/L) or phenylephrine (1 micromol/L) was attenuated by isosteviol from 0.01 micromol/L to 10 micromol/L. Furthermore, the inhibitory action of isosteviol on [Ca (2+)]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present[4]. Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion[5].
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