There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor by preventing the DNA strand's religation through its binding to the topoisomerase I-DNA complex[1].
体内研究
Administered as Irinotecan (CPT-11, 5 mg/kg) through daily intratumoral injections for five days across two successive weeks in rats, and via continuous intraperitoneal infusion using an osmotic minipump in mice, it notably impedes tumor growth, whereas a dosage of 10 mg/kg exhibits no significant tumor growth inhibition by intraperitoneal injection[1].
Furthermore, Irinotecan (CPT-11, 100-300 mg/kg, i.p.) markedly diminishes tumor growth in HT-29 xenografts within athymic female mice by the 21st day. Combination treatments of Irinotecan (125 mg/kg) with TSP-1 (10 mg/kg per day) and Irinotecan (150 mg/kg) with TSP-1 (20 mg/kg per day) achieve tumor growth inhibition rates of 84% and 89%, respectively, surpassing the efficacy of Irinotecan alone at dosages of 250 and 300 mg/kg[3].
体外研究
As a potent topoisomerase I inhibitor, Irinotecan curtails the proliferation of LoVo and HT-29 cells, presenting IC50 values of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively, and similarly induces cleavable complexes in both cell types[2].
Irinotecan also hampers the growth of human umbilical vein endothelial cells (HUVEC), showcasing an IC50 of 1.3 μM[3].
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HazMat Fee +
