产品说明书

Irinotecan hydrochloride

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Chemical Structure| 100286-90-6 同义名 : 盐酸伊立替康 ;CPT-11 hydrochloride;VAL-413;(+)-Irinotecan hydrochloride
CAS号 : 100286-90-6
货号 : A309111
分子式 : C33H39ClN4O6
纯度 : 98%
分子量 : 623.139
MDL号 : -
存储条件:

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(192.57 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 3 mg/mL(4.81 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor by preventing the DNA strand's religation through its binding to the topoisomerase I-DNA complex[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.02mL

1.60mL

0.80mL

16.05mL

3.21mL

1.60mL

参考文献

[1]Morales C, et al. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb;56(3):219-26.

[2]Pavillard V, et al. Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. Cancer Chemother Pharmacol. 2002 Apr;49(4):329-35. Epub 2002 Jan 30.

[3]Allegrini G, et al. Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice. Cancer Chemother Pharmacol. 2004 Mar;53(3):261-6. Epub 2003 Dec 5.