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Flumequine

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Chemical Structure| 42835-25-6 同义名 : R-802;(±)-Flumequine
CAS号 : 42835-25-6
货号 : A127261
分子式 : C14H12FNO3
纯度 : 98%
分子量 : 261.248
MDL号 : MFCD00079298
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 6 mg/mL(22.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Topo II

    Topo II, IC50:15 μM
描述 Flumequine (R-802) acts as a topoisomerase II inhibitor, with an IC50 of 3.92 μg/mL, and inhibits Gyrase less effectively, with an IC50 of 1764 μg/mL. Flumequine (0-625 μg/mL) leads to increased migration of nuclear DNA from CHL cells[1]. Flumequine (R-802) effectively inhibits Spanish field isolates of B. hyodysenteriae with MIC50 and MIC90 of 50 and 100 μg/mL, and MBC50 and MBC90 of 50, 200 μg/mL, respectively[2]. Flumequine (R-802) inhibits A. salmonicida isolates with MIC values ranging from 0.06 to 32 μg/mL[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02068664 - Completed - United States, New Jersey ... 展开 >> Adler Aphasia Center Maywood, New Jersey, United States, 07607 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.83mL

0.77mL

0.38mL

19.14mL

3.83mL

1.91mL

38.28mL

7.66mL

3.83mL
参考文献

[1]Kashida Y, et al. Mechanistic study on flumequine hepatocarcinogenicity focusing on DNA damage in mice. Toxicol Sci. 2002 Oct;69(2):317-21.

[2]Aller-Morán LM, et al. Evaluation of the in vitro activity of flumequine against field isolates of Brachyspira hyodysenteriae. Res Vet Sci. 2015 Dec;103:51-3.

[3]Giraud E, et al. Mechanisms of quinolone resistance and clonal relationship among Aeromonas salmonicida strains isolated from reared fish with furunculosis. J Med Microbiol. 2004 Sep;53(Pt 9):895-901.