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/ Exatecan mesylate dihydrate

Exatecan mesylate dihydrate 95%

货号：A293901 同义名： DX-8951 mesylate dihydrate Ambeed 开学季，买赠积分，赢豪礼

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
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Inaccessible (Haz class 6.1), Domestic USD 80+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Exatecan mesylate dihydrate 化学结构 CAS号：197720-53-9
Exatecan mesylate dihydrate 化学结构
CAS号：197720-53-9
Exatecan mesylate dihydrate 3D分子结构
CAS号：197720-53-9
Exatecan mesylate dihydrate 化学结构 CAS号：197720-53-9
Exatecan mesylate dihydrate 3D分子结构 CAS号：197720-53-9
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Exatecan mesylate dihydrate 纯度/质量文件 产品仅供科研

货号：A293901 标准纯度： 95%
批次查询： 批次纯度:

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone dihydrochloride ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 98%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 97%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Exatecan mesylate dihydrate 生物活性

描述 Exatecan mesylate dihydrate (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), suitable for application in cancer research [1][2][3].

Exatecan mesylate dihydrate 参考文献

[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

[2]Sun FX, et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63(1):80-5.

[3]Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72(4):680-6.

Exatecan mesylate dihydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.82mL

0.36mL

0.18mL

9.10mL

1.82mL

0.91mL

18.20mL

3.64mL

1.82mL

Exatecan mesylate dihydrate 技术信息

CAS号197720-53-9
分子式C25H28FN3O8S
分子量 549.568
别名 DX-8951 mesylate dihydrate
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度
动物实验配方

Tags: Exatecan mesylate dihydrate | 197720-53-9 | DX-8951 mesylate dihydrate | Topoisomerase | Topoisomerase I Inhibitor | Cell Cycle/DNA Damage | Antibody-drug Conjugate/ADC Related | Topoisomerase | ADC Cytotoxin | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Exatecan mesylate dihydrate 纯度/质量文件 | Exatecan mesylate dihydrate 亚型比较 | Exatecan mesylate dihydrate 生物活性 | Exatecan mesylate dihydrate 参考文献 | Exatecan mesylate dihydrate 实验方案 | Exatecan mesylate dihydrate 技术信息

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