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货号 产品名 纯度
A309085 现货 Monomethyl Auristatin F

MMAF can inhibit tubulin polymerization used in ADCs, with lower cytotoxic activity than MMAE.

99%+
A348562 现货 DM4

Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).

99%+
A106511 现货 Monomethyl Auristatin D

MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

99%+
A880207 现货 Maytansinol

Maytansinol (Ansamitocin P-0) 是从 Maytansine 衍生出的,具有阻止微管聚合和触发细胞凋亡的能力,具有抗肿瘤潜力。

99%+
A516438 现货 Auristatin F/澳瑞他汀 F

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.

99%+
A172961 现货 Monomethyl auristatin E/一甲基澳瑞他汀 E

Monomethyl auristatin E(MMAE;SGD-1010)是杜氏素10的合成衍生物,通过抑制微管蛋白聚合而起到强效有丝分裂抑制剂的作用。MMAE广泛用于抗体-药物结合物(ADC)的细胞毒性成分,以治疗各种癌症。

99%+
A686559 现货 DM1

DM1(Mertansine)是一种微管抑制剂和抗体可结合的美坦新类物质,旨在克服美坦新的全身毒性并增强肿瘤特异性递送。美坦新可以通过连接子附着到单克隆抗体上,以形成抗体-药物结合物(ADC)。

99%+
A159572 现货 Ansamitocin P-3/安丝菌素P 3

Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.

98% P-3 major, mix(P-0, P-1, P-2, P-3, P-3’, P-4, P-4’)
A210355 现货 Eribulin/艾日布林

Eribulin, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.

98%
A1216715 现货 DRF-1042

DRF-1042是一种具有口服活性的喜树碱类似物,作为 DNA 拓扑异构酶 I 的抑制剂,能够有效阻止癌细胞 DNA 复制,适用于多药耐药癌症的研究。

98%
A619128 现货 Exatecan/依喜替康

Exatecan (DX-8951) 是一种具有 2.2 μM (0.975 μg/mL) IC50DNA 拓扑异构酶 I 抑制剂,用于癌症研究。

98%
A700623 现货 MMAF-OMe/MMAF-Ome甲酯

MMAF-OMe is a synthetic antineoplastic agent and also used as a part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.

99%+
A293901 现货 Exatecan mesylate dihydrate

95%
A838144 现货 Exatecan Intermediate 2

99%+
A866930 现货 DM1-SMe

DM1-SMe 是 IMGN901 中 Maytansinoid 的非结合形式。在一组人类肿瘤细胞系中,DM1-SMe 比母体 Maytansinoid 强效约 3-10 倍,IC50 值在 0.003 到 0.01 nM 之间

98%+
A1678589 现货 Inebilizumab/伊奈利珠单抗

Inebilizumab是一种人源化IgG1单克隆抗体,通过与CD19抗原结合来耗竭B细胞。Inebilizumab具有用于视神经脊髓炎谱系疾病研究的潜力。

95%
A631658 现货 10-Methoxycamptothecin/10-甲氧基喜树碱

10-Methoxycamptothecin is isolated from the barks of camptotheca acuminata decne which possesses high anti-cancer activity.

98%
A439063 现货 10-Deacetyl-7-xylosyl paclitaxel

7-Xylosyl-10-deacetyltaxol is a paclitaxel derivative with improved pharmacological features and higher water solubility.

98%
A316515 现货 Sipeimine/西贝母碱

Imperialine is a natural product isolated and purified from the bulbus of Fritillaria thunbergii Miq. with antiasthmatic effect,on tracheal M receptor antagonist.

98+%
A378071 Dolastatin 10/多拉司他丁 10

Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)

99%+
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