MMAF can inhibit tubulin polymerization used in ADCs, with lower cytotoxic activity than MMAE.

Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).

MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

Maytansinol (Ansamitocin P-0) 是从 Maytansine 衍生出的，具有阻止微管聚合和触发细胞凋亡的能力，具有抗肿瘤潜力。

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.

Monomethyl auristatin E（MMAE；SGD-1010）是杜氏素10的合成衍生物，通过抑制微管蛋白聚合而起到强效有丝分裂抑制剂的作用。MMAE广泛用于抗体-药物结合物（ADC）的细胞毒性成分，以治疗各种癌症。

DM1（Mertansine）是一种微管抑制剂和抗体可结合的美坦新类物质，旨在克服美坦新的全身毒性并增强肿瘤特异性递送。美坦新可以通过连接子附着到单克隆抗体上，以形成抗体-药物结合物（ADC）。

Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.

Eribulin, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.

Piericidin A是一种线粒体 NADH^-泛醌氧化还原酶抑制剂，能够阻断电子传输，具有抗菌、抗癌和杀虫活性，同时也可作为群体感应抑制剂，适用于癌症及感染性疾病研究。

DRF-1042是一种具有口服活性的喜树碱类似物，作为 DNA 拓扑异构酶 I 的抑制剂，能够有效阻止癌细胞 DNA 复制，适用于多药耐药癌症的研究。

Exatecan (DX-8951) 是一种具有 2.2 μM (0.975 μg/mL) IC50 的 DNA 拓扑异构酶 I 抑制剂，用于癌症研究。

MMAF-OMe is a synthetic antineoplastic agent and also used as a part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.

DM1-SMe 是 IMGN901 中 Maytansinoid 的非结合形式。在一组人类肿瘤细胞系中，DM1-SMe 比母体 Maytansinoid 强效约 3-10 倍，IC50 值在 0.003 到 0.01 nM 之间

Inebilizumab是一种人源化IgG1单克隆抗体，通过与CD19抗原结合来耗竭B细胞。Inebilizumab具有用于视神经脊髓炎谱系疾病研究的潜力。

10-Methoxycamptothecin is isolated from the barks of camptotheca acuminata decne which possesses high anti-cancer activity.

7-Xylosyl-10-deacetyltaxol is a paclitaxel derivative with improved pharmacological features and higher water solubility.

Imperialine is a natural product isolated and purified from the bulbus of Fritillaria thunbergii Miq. with antiasthmatic effect,on tracheal M receptor antagonist.