MMAF can inhibit tubulin polymerization used in ADCs, with lower cytotoxic activity than MMAE.

Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).

MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

Maytansinol (Ansamitocin P-0) 是从 Maytansine 衍生出的，具有阻止微管聚合和触发细胞凋亡的能力，具有抗肿瘤潜力。

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.

Monomethyl auristatin E（MMAE；SGD-1010）是杜氏素10的合成衍生物，通过抑制微管蛋白聚合而起到强效有丝分裂抑制剂的作用。MMAE广泛用于抗体-药物结合物（ADC）的细胞毒性成分，以治疗各种癌症。

DM1（Mertansine）是一种微管抑制剂和抗体可结合的美坦新类物质，旨在克服美坦新的全身毒性并增强肿瘤特异性递送。美坦新可以通过连接子附着到单克隆抗体上，以形成抗体-药物结合物（ADC）。

Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.

Eribulin, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules.

Inebilizumab是一种人源化IgG1单克隆抗体，通过与CD19抗原结合来耗竭B细胞。Inebilizumab具有用于视神经脊髓炎谱系疾病研究的潜力。

MMAF-OMe is a synthetic antineoplastic agent and also used as a part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.

DM1-SMe 是 IMGN901 中 Maytansinoid 的非结合形式。在一组人类肿瘤细胞系中，DM1-SMe 比母体 Maytansinoid 强效约 3-10 倍，IC50 值在 0.003 到 0.01 nM 之间

10-Methoxycamptothecin is isolated from the barks of camptotheca acuminata decne which possesses high anti-cancer activity.

7-Xylosyl-10-deacetyltaxol is a paclitaxel derivative with improved pharmacological features and higher water solubility.

Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)