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/ Diclofenac Diethylamine

双氯芬酸二乙胺盐 /Diclofenac Diethylamine {[allProObj[0].p_purity_real_show]}

货号：A115940 同义名： 双氯芬酸二乙胺 / Diclofenac (diethylamine)

Diclofenac diethylamine is a non-selective COX inhibitor used as a nonsteroidal anti-inflammatory drug (NSAID).

Diclofenac Diethylamine 化学结构 CAS号：78213-16-8
Diclofenac Diethylamine 化学结构
CAS号：78213-16-8
Diclofenac Diethylamine 3D分子结构
CAS号：78213-16-8
Diclofenac Diethylamine 化学结构 CAS号：78213-16-8
Diclofenac Diethylamine 3D分子结构 CAS号：78213-16-8
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Diclofenac Diethylamine 纯度/质量文件 产品仅供科研

货号：A115940 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 99%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Rofecoxib ++++

COX-2, IC50: 18 nM

 		98%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		98%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Diclofenac Diethylamine 生物活性

描述 Diclofenac diethylamine acts as a potent and nonselective anti-inflammatory agent by inhibiting both COX-1 and COX-2, with IC50 values of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1]. Diclofenac diethylamine triggers apoptosis in neural stem cells (NSCs) by activating the caspase cascade[3].
体内研究

Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly elevates faecal 51Cr excretion in rats. A similar effect is observed in squirrel monkeys when administered 1 mg/kg twice daily for 4 days[1].

Diclofenac (10 mg/kg) demonstrates anti-inflammatory activity in Wistar rats in vivo[1].
体外研究

Diclofenac effectively inhibits the production of COX-1 mediated prostanoids from U937 cell microsomes, exhibiting an IC50 of 7±3 nM[1].

Diclofenac (1-60 μM; 1 day) triggers the death of neural stem cells (NSCs)[3].

Diclofenac (10-60 μM) upregulates the expression of cleaved (activated) caspase-3 within 6 hours[3].

Diclofenac Diethylamine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03434197 Osteoarthritis Knee Pain Phase 3 Recruiting September 30, 2019 Indonesia ... 展开 >> Klinik Perisai Husada Recruiting Bandung, Indonesia Contact: Laniyati Hamijoyo, Dr. Sp.PD-KR          Rumah Sakit Hasan Sadikin Recruiting Bandung, Indonesia Contact: Rachmat Gunadi Wachjudi, Dr. Sp.PD-KR          Rumah Sakit Umum Daerah Al Ihsan Bale Endah Recruiting Bandung, Indonesia Contact: Andri Reza, Dr. Sp.PD-KR          Rumah Sakit Anna Medika Bekasi Recruiting Jakarta, Indonesia Contact: Ika Wulan Yuliani, Dr. Sp.PD-KR          Rumah Sakit Islam Pd. Kopi Recruiting Jakarta, Indonesia Contact: Tanggo Meriza, Dr. Sp.PD-KR          Rumah Sakit Siloam Karawaci Recruiting Jakarta, Indonesia Contact: Sandra Sinthya Langow, Dr. Sp.PD-KR 收起 <<
NCT01335724 Neck Pain Phase 4 Completed - Germany ... 展开 >> NCH investigative site Cologne, Germany NCH investigative site Essen, Germany NCH investigative site Munich, Germany 收起 <<
NCT01335724 - Completed - -

Diclofenac Diethylamine 参考文献

[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.

[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95.

Diclofenac Diethylamine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.54mL

2.71mL

1.35mL

27.08mL

5.42mL

2.71mL

Diclofenac Diethylamine 技术信息

CAS号78213-16-8
分子式C18H22Cl2N2O2
分子量 369.286
别名 双氯芬酸二乙胺 ;Diclofenac (diethylamine)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 145 mg/mL(392.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Diclofenac | 78213-16-8 | COX Inhibitor | Immunology/Inflammation | Apoptosis | COX | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Diclofenac Diethylamine 纯度/质量文件 | Diclofenac Diethylamine 亚型比较 | Diclofenac Diethylamine 生物活性 | Diclofenac Diethylamine 临床数据 | Diclofenac Diethylamine 参考文献 | Diclofenac Diethylamine 实验方案 | Diclofenac Diethylamine 技术信息

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