产品说明书
Diclofenac Diethylamine
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同义名 : | 双氯芬酸二乙胺 ;Diclofenac (diethylamine) |
| CAS号 : | 78213-16-8 | |
| 货号 : | A115940 | |
| 分子式 : | C18H22Cl2N2O2 | |
| 纯度 : | 98% | |
| 分子量 : | 369.286 | |
| MDL号 : | MFCD01862249 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 145 mg/mL(392.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Diclofenac diethylamine acts as a potent and nonselective anti-inflammatory agent by inhibiting both COX-1 and COX-2, with IC50 values of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1]. Diclofenac diethylamine triggers apoptosis in neural stem cells (NSCs) by activating the caspase cascade[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03434197 | Osteoarthritis Knee Pain | Phase 3 | Recruiting | September 30, 2019 | Indonesia ... 展开 >> Klinik Perisai Husada Recruiting Bandung, Indonesia Contact: Laniyati Hamijoyo, Dr. Sp.PD-KR Rumah Sakit Hasan Sadikin Recruiting Bandung, Indonesia Contact: Rachmat Gunadi Wachjudi, Dr. Sp.PD-KR Rumah Sakit Umum Daerah Al Ihsan Bale Endah Recruiting Bandung, Indonesia Contact: Andri Reza, Dr. Sp.PD-KR Rumah Sakit Anna Medika Bekasi Recruiting Jakarta, Indonesia Contact: Ika Wulan Yuliani, Dr. Sp.PD-KR Rumah Sakit Islam Pd. Kopi Recruiting Jakarta, Indonesia Contact: Tanggo Meriza, Dr. Sp.PD-KR Rumah Sakit Siloam Karawaci Recruiting Jakarta, Indonesia Contact: Sandra Sinthya Langow, Dr. Sp.PD-KR 收起 << |
| NCT01335724 | Neck Pain | Phase 4 | Completed | - | Germany ... 展开 >> NCH investigative site Cologne, Germany NCH investigative site Essen, Germany NCH investigative site Munich, Germany 收起 << |
| NCT01335724 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.71mL 0.54mL 0.27mL |
13.54mL 2.71mL 1.35mL |
27.08mL 5.42mL 2.71mL |
| 参考文献 |
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