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抑制剂/激动剂
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细胞周期 肿瘤表观遗传和基因调控
/ 拓扑异构酶 / (4-NH2)-Exatecan

(4-NH2)-Exatecan {[allProObj[0].p_purity_real_show]}

货号：A1531421

(4-NH2)-Exatecan是 Exatecan 的衍生物，作为一种拓扑异构酶抑制剂，可用于合成抗体偶联药物 (ADC)。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
(4-NH2)-Exatecan 化学结构 CAS号：2495742-21-5
(4-NH2)-Exatecan 化学结构
CAS号：2495742-21-5
(4-NH2)-Exatecan 3D分子结构
CAS号：2495742-21-5
(4-NH2)-Exatecan 化学结构 CAS号：2495742-21-5
(4-NH2)-Exatecan 3D分子结构 CAS号：2495742-21-5
规格 价格 会员价 库存 数量
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(4-NH2)-Exatecan 纯度/质量文件 产品仅供科研

货号：A1531421 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone dihydrochloride ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 98%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 97%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(4-NH2)-Exatecan 生物活性

描述 (4-NH2)-Exatecan, a topoisomerase inhibitor and a derivative of Exatecan, is being studied for use in the development of antibody-drug conjugates (ADCs), as outlined in US20200306243A1, compound A[1].
体外研究

(4-NH2)-Exatecan includes a linker that attaches in a cleavable manner to the amino residue, marked by an added amino (NH2) functional group at the 4th position of the parent molecule[1].

(4-NH2)-Exatecan 参考文献

[1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.

(4-NH2)-Exatecan 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.39mL

2.48mL

1.24mL

24.79mL

4.96mL

2.48mL

(4-NH2)-Exatecan 技术信息

CAS号2495742-21-5
分子式C23H21N3O4
分子量 403.431
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(260.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: (4-NH2)-Exatecan | 2495742-21-5 | Topoisomerase | antibody-drug | Topoisomerase Inhibitor | Cell Cycle/DNA Damage | Topoisomerase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | (4-NH2)-Exatecan 纯度/质量文件 | (4-NH2)-Exatecan 亚型比较 | (4-NH2)-Exatecan 生物活性 | (4-NH2)-Exatecan 参考文献 | (4-NH2)-Exatecan 实验方案 | (4-NH2)-Exatecan 技术信息

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