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(-)-表儿茶素 /(-)-Epicatechin {[allProObj[0].p_purity_real_show]}

货号:A121952 同义名: 表儿茶素;表儿茶精 / (-)-Epicatechol;NSC 81161

(-)-Epicatechin is a polyphenolic flavonoid that can act as an inhibitor of COX-1 (IC50 = 3.2 μM) and has activities of antioxidant, lipid-lowering and hypoglycemic, prevent cardiovascular diseases. (−)-Epicatechin is a 2R,3R stereoisomer of catechin.

(-)-Epicatechin 化学结构 CAS号:490-46-0
(-)-Epicatechin 化学结构
CAS号:490-46-0
(-)-Epicatechin 3D分子结构
CAS号:490-46-0
(-)-Epicatechin 化学结构 CAS号:490-46-0
(-)-Epicatechin 3D分子结构 CAS号:490-46-0
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(-)-Epicatechin 纯度/质量文件 产品仅供科研

货号:A121952 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 COX COX-1 COX-2 其他靶点 纯度
Piroxicam 98%
Salicylic acid 98%
Phenacetin 98%
Etodolac 99%
Flunixin meglumine 98%
Ibuprofen L-lysine 99%
Nabumetone 98%
Acemetacin 98%
Diflunisal 98%
Pranoprofen 98%
Ampiroxicam 98%
Meloxicam 98%
Sulindac 98%
Ketoprofen 98%
Mefenamic Acid 95%
Bromfenac sodium 98%
Oxaprozin 99%
Aspirin 99%
Nepafenac 98%
Zaltoprofen 99%
Salicin 98%
Suprofen 99%+
Xanthohumol 99%
Parecoxib 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

98%
Etoricoxib 99%
Niflumic Acid 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

99+%
Ibuprofen +

COX-1, IC50: 13 μM

+

COX-2, IC50: 370 μM

98%
Indomethacin ++

COX1, IC50: 0.28 μM

+

COX-2, IC50: 14 μM

97%
Lornoxicam ++++

COX-1, IC50: 5 nM

++++

COX-2, IC50: 8 nM

98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

+++

COX-2, IC50: 50 nM

99%
Rofecoxib ++++

COX-2, IC50: 18 nM

98%
Asaraldehyde 98%
Naproxen +

COX-1, IC50: 8.7 μM

+

COX-2, IC50: 5.2 μM

98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

+++

COX-2, IC50: 200 nM

98%
NS-398 ++

COX-2, IC50: 3.8 μM

98%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

+++

COX-2, IC50: 150 nM

98%+
Nimesulide +

COX-2, IC50: 26 μM

98%
Lumiracoxib ++

COX-1, Ki: 3 μM

+++

COX-2, Ki: 60 nM

98%
Rutaecarpine 95%
Celecoxib ++++

COX-2, IC50: 40 nM

98%
Carprofen ++++

canine COX2, IC50: 30 nM

98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

++

COX-2 (human), IC50: 3.50 μM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

(-)-Epicatechin 生物活性

描述 (−)-Epicatechin, as a flavanols, is found as a natural product in cacao and cacao products, such as dark chocolate, and in green tea. (−)-Epicatechin potently reduced luciferase expression (EC50 of 20.5 nM) at 6 hours. Neurons were treated with (−)-epicatechin (100 nM for 6 hours), (−)-Epicatechin decreased Aβ1-40 levels by approximately 30%[3]. In vivo, high-flavonoid dark chocolate containing 46 mg (−)-epicatechin daily for 2 weeks showed superior vascular function as seen by improved endothelium-dependent flow-mediated dilation of the brachial artery. Moreover, a reduction in ovalbumin-specific IgE present in the mice fed with the high dose (26 ± 13 ng/mL) and medium dose (89 ± 35 ng/mL) of (−)-epicatechin [4].

(-)-Epicatechin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01360320 Colorectal Serrated Adenomas ... 展开 >> Colorectal Tubular Adenomas Colorectal Villous Adenomas Colorectal Tubulovillous Adenomas 收起 << Phase 2 Unknown March 2018 Germany ... 展开 >> Ostalb-Klinikum Aalen, Medizinische Klinik 1, Sekretariat Prof. Kleber Recruiting Aalen, Germany, 73430 Contact: Caroline Walny       caroline.walny@ostalb-klinikum.de    Principal Investigator: Gerhard Kleber, MD          Klinikum Altenburger Land, Gastroenterologie Not yet recruiting Altenburg, Germany, 04600 Contact: Michael Repp, MD       michael.repp@klinikum-altenburgerland.de    Principal Investigator: Michael Repp, MD          Klinikum Augsburg, III. Med. Klinik Recruiting Augsburg, Germany, 86156 Contact: Tanja Hilmer       Tanja.Hilmer@klinikum-augsburg.de    Krankenhaus Bietigheim-Bissingen, Klinik für Innere Medizin, Gastroenterologie, Hämato-Onkologie Recruiting Bietigheim-Bissingen, Germany, 74321 Contact: Ulla Hegmann       hegmul01@kliniken-lb.de    Principal Investigator: Siegfried Walker, MD          Krankenhaus Buchholz, Abteilung Innere Medizin Recruiting Buchholz, Germany, 21244 Contact: Dirk Fahrenholz, MD       Dirk.Fahrenholz@krankenhaus-buchholz.de    Principal Investigator: Dirk Fahrenholz, MD          Kliniken der Stadt Köln gGmbH, Krankenhaus Holweide -Medizinische Klinik- Recruiting Cologne, Germany Contact: Claudia Kaiser-Stolz       Kaiser-Stolz@kliniken-koeln.de    Principal Investigator: Ulrich Huegle, MD          Klinikum Esslingen, Klinik für Innere Medizin, Onkologie, Gastroenterologie Recruiting Esslingen, Germany, 73730 Contact: Stephanie Klink       s.klink@kliniken-es.de    Principal Investigator: Michael Geissler, MD          Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, Klinik und Poliklinik für Innere Medizin A Recruiting Greifswald, Germany, 17475 Contact: Eckhard Weber       eckhard.weber@uni-greifswald.de    Principal Investigator: Julia Mayerle, MD          Dr. Zeisler, Praxis für Innere Medizin und Gastroenterologie Recruiting Halle, Germany, 06108 Contact: Brigitte Schneider       gastrozeisler@yahoo.de    Principal Investigator: Thomas Zeisler, MD          Dres. Fechner/Behrens/Steudel - Gastroenterologisch-Onkologische Praxisklinik Recruiting Halle, Germany, 06108 Contact: Anja Schlenk       bsf@gastro-halle.de    Principal Investigator: Ruediger Behrens, MD          Dr. Frank-Gleich Praxis für Innere Medizin und Gastroenterologie Recruiting Halle, Germany, 06110 Contact: Ute Kabisch       u.kabisch@onkomedic.de    Principal Investigator: Stefanie Frank-Gleich, MD          Universitätsklinikum Halle, Klinik für Innere Medizin I Recruiting Halle, Germany, 06120 Contact: Teuber Evelin       evelin.teuber@medizin.uni-halle.de    Principal Investigator: Thomas Seufferlein, MD          Sub-Investigator: Thomas J. Ettrich, MD          Klinikum Ludwigsburg, Medizinische Klinik I Recruiting Ludwigsburg, Germany, 71640 Contact: Samuel Raad       samuel.raad@kliniken-lb.de    Principal Investigator: Karel Caca, MD          Diakoniekrankenhaus Mannheim, Medizinische Klinik II Recruiting Mannheim, Germany, 68163 Contact: Ulrich Damian, MD       u.damian@diako-ma.de    Principal Investigator: Ulrich Damian, MD          II. Medizinische Klinik und Poliklinik der TU München, Klinikum rechts der Isar Recruiting Munich, Germany, 81675 Contact: Jens Zimmermann       Studiensekretariat.med2@lrz.tum.de    Principal Investigator: Jens T. Siveke, MD          Klinik Mühldorf Abt.Gastroenterologie Recruiting Mühldorf am Inn, Germany, 84453 Contact: Melanie Mühlberger       melanie.muehlberger@kliniken-muehldorf.de    Principal Investigator: Gerhard Fuechsl, MD          Klinikum Bogenhausen, Interdisziplinäre Onkologische Tagklinik Recruiting München, Germany, 81525 Contact: Romy Petermann       romy.petermann@klinikum-muenchen.de    Principal Investigator: Martin Fuchs, MD          Regio Kliniken Pinneberg Not yet recruiting Pinneberg, Germany, 25421 Contact: Stefan Tardos, MD       stefan.tardos@regiokliniken.de    Principal Investigator: Stefan Tardos, MD          Klinikum St. Elisabeth, I. Medizinische Klinik Recruiting Straubing, Germany, 94315 Contact: Stefanie Wolf       stefanie.wolf@klinikum-straubing.de    Principal Investigator: Weigert Norbert, MD          Universitätsklinikum Ulm, Klinik für Innere Medizin I Recruiting Ulm, Germany, 89081 Contact: Yvonne Kriebisch       yvonne.kriebisch@uniklinik-ulm.de    Principal Investigator: Goetz von Wichert, MD          Evangelisches Krankenhaus Wesel, Abteilung Innere Medizin Recruiting Wesel, Germany, 46485 Contact: Adelheid Rosendahl       rosendahl@evkwesel.de    Principal Investigator: Dirk Hartnack, MD 收起 <<
NCT02447783 Healthy Not Applicable Completed - United States, California ... 展开 >> Ragle Human Nutrition Research Center, Department of Nutrition at UC Davis Davis, California, United States, 95616 收起 <<
NCT02422745 Cardiovascular Disease ... 展开 >> Cancer 收起 << Phase 4 Active, not recruiting October 2020 United States, Massachusetts ... 展开 >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02215 United States, Washington Fred Hutchinson Cancer Research Center Seattle, Washington, United States, 98109 收起 <<

(-)-Epicatechin 参考文献

[1]Gutierrez-Salmean G, Ciaraldi TP, et al. Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem. 2014 Jan;25(1):91-4.

[2]Huttemann M, Lee I, Malek MH. (-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining. FASEB J. 2012 Apr;26(4):1413-22.

[3]Cox CJ, Choudhry F, Peacey E, Perkinton MS, Richardson JC, Howlett DR, Lichtenthaler SF, Francis PT, Williams RJ. Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. Neurobiol Aging. 2015 Jan;36(1):178-87. doi: 10.1016/j.neurobiolaging.2014.07.032. Epub 2014 Jul 30. PMID: 25316600; PMCID: PMC4270442.

[4]Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH, Hüttemann M. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260. doi: 10.1155/2015/181260. Epub 2015 Jun 9. PMID: 26180580; PMCID: PMC4477097.

(-)-Epicatechin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.45mL

0.69mL

0.34mL

17.23mL

3.45mL

1.72mL

34.45mL

6.89mL

3.45mL

(-)-Epicatechin 技术信息

CAS号490-46-0
分子式C15H14O6
分子量 290.268
别名 表儿茶素;表儿茶精 ;(-)-Epicatechol;NSC 81161;l-Epicatechol;l-Acacatechin;(2R,3R)-(-)-Epicatechin;Epicatechol;(−)-Epicatechin;L-Epicatechin;Epicatechin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 105 mg/mL(361.73 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 2 mg/mL(6.89 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方
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