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Salicin

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Chemical Structure| 138-52-3 同义名 : D(-)-水杨苷 ;D-(−)-Salicin;Salicoside;D-(-)-Salicin;NSC 5751
CAS号 : 138-52-3
货号 : A190057
分子式 : C13H18O7
纯度 : 98%
分子量 : 286.278
MDL号 : MFCD00006590
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(506.5 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(41.92 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
靶点

  • COX-1
描述 Salicin is a natural COX inhibitor. At the cellular level, salicin attenuates IL-1β-induced mitochondrial injury as revealed by its preservation on mitochondrial membrane potential (MMP). Furthermore, salicin inhibits IL-1β-induced production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1) [3]. Salicin significantly reduced cell viability, cytokines, and matrix metalloproteinases-1/-3 expression in IL-1β-induced RA-FLSs and inhibited ROS generation and p65 phosphorylation as compared with IL-1β-induced treatment. Moreover, salicin promoted Nrf2 nuclear translocation and HO-1 expression and reduced ROS production in IL-1β-induced RA-FLSs[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01920841 Weight Loss Not Applicable Withdrawn(Study Design changed... 展开 >> and will be resubmitted as a new study) 收起 << - United States, Louisiana ... 展开 >> Pennington Biomedical Research Center Baton Rouge, Louisiana, United States, 70808 收起 <<
NCT01956500 Joint Pain, Stiffness, Functio... 展开 >>n 收起 << Not Applicable Completed - United States, North Carolina ... 展开 >> ASU Human Performance Laboratory, North Carolina Research Campus Kannapolis, North Carolina, United States, 28081 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

1.75mL

34.93mL

6.99mL

3.49mL
参考文献

[1]Akao T, Yoshino T, et al. Evaluation of salicin as an antipyretic prodrug that does not cause gastric injury. Planta Med. 2002 Aug;68(8):714-8.

[2]Maclagan T. The Treatment of Rheumatism by Salicin and Salicylic Acid. Br Med J. 1876 May 20;1(803):627.

[3]Song Y, Tian X, Wang X, Feng H. Vascular protection of salicin on IL-1β-induced endothelial inflammatory response and damages in retinal endothelial cells. Artif Cells Nanomed Biotechnol. 2019;47(1):1995-2002

[4]Zhai KF, Duan H, Khan GJ, et al. Salicin from Alangium chinense Ameliorates Rheumatoid Arthritis by Modulating the Nrf2-HO-1-ROS Pathways. J Agric Food Chem. 2018;66(24):6073-6082