Fenbufen | 3-(4-联苯羰基)丙酸 | CL-82204 | Anti-inflammatory Compound

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Fenbufen {[allProObj[0].p_purity_real_show]}

货号：A819665 同义名： 3-(4-联苯羰基)丙酸 / CL-82204; Lederfen

Fenbufen是一种苯基烷基衍生物，具有抗炎、镇痛和退热作用，是一种非甾体抗炎药。

Fenbufen 化学结构
CAS号：36330-85-5

Fenbufen 3D分子结构
CAS号：36330-85-5

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Fenbufen 纯度/质量文件产品仅供科研

货号：A819665 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Adv. Funct. Mater., 2025, 2500696. Ambeed. [ A245395 ]; • JACS, 2025. Ambeed. [ A505336 ]; • Sci. Adv., 2025, 11(13): eadr0006. Ambeed. [ A152627 ]; • ACS Appl. Mater. Interfaces, 2025, 17(12): 18046-18058. Ambeed. [ A739356 , A171817 ]; • Food Res. Int., 2025, 116191. Ambeed. [ A1452012 ]; 更多 >

环氧化酶亚型比较

产品名称	COX ↓ ↑	COX-1 ↓ ↑	COX-2 ↓ ↑	纯度
Piroxicam	✔			98%
Salicylic acid	✔			98%
Phenacetin	✔			98%
Etodolac	✔			99%
Flunixin meglumine	✔			98%
Ibuprofen L-lysine	✔			99%
Nabumetone	✔			98%
Acemetacin	✔			98%
Diflunisal	✔			98%
Pranoprofen	✔			98%
Ampiroxicam	✔			98%
Meloxicam	✔			98%
Sulindac	✔			98%
Ketoprofen		✔		98%
Mefenamic Acid		✔		95%
Bromfenac sodium		✔		98%
Oxaprozin		✔		99%
Aspirin		✔		99%
Nepafenac		✔		98%
Zaltoprofen		✔		99%
Salicin		✔		98%
Suprofen		✔		99%+
Xanthohumol		✔		99%
Parecoxib			✔	98%
Tolfenamic Acid			+++ COX-2, IC50: 0.2 μM	98%
Etoricoxib			✔	99%
Niflumic Acid			✔	98%
Valdecoxib			++++ COX-2, IC50: 5 nM	99+%
Ibuprofen		+ COX-1, IC50: 13 μM	+ COX-2, IC50: 370 μM	98%
Indomethacin		++ COX1, IC50: 0.28 μM	+ COX-2, IC50: 14 μM	97%
Lornoxicam		++++ COX-1, IC50: 5 nM	++++ COX-2, IC50: 8 nM	98%
Meclofenamic acid sodium		++++ COX-1, IC50: 40 nM	+++ COX-2, IC50: 50 nM	99%
Rofecoxib			++++ COX-2, IC50: 18 nM	98%
Asaraldehyde			✔	98%
Naproxen		+ COX-1, IC50: 8.7 μM	+ COX-2, IC50: 5.2 μM	98%
Diclofenac Sodium Salt		+++ COX-1, IC50: 60 nM	+++ COX-2, IC50: 200 nM	98%
NS-398			++ COX-2, IC50: 3.8 μM	95%
Amfenac Sodium Hydrate		++ COX-1, IC50: 250 nM	+++ COX-2, IC50: 150 nM	98%+
Nimesulide			+ COX-2, IC50: 26 μM	98%
Lumiracoxib		++ COX-1, Ki: 3 μM	+++ COX-2, Ki: 60 nM	99%
Rutaecarpine			✔	95%
Celecoxib			++++ COX-2, IC50: 40 nM	98%
Carprofen			++++ canine COX2, IC50: 30 nM	98%
Ketorolac		++ COX-1 (human), IC50: 1.23 μM	++ COX-2 (human), IC50: 3.50 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Fenbufen 生物活性

描述

Fenbufen is a non-selective non-steroidal anti-inflammatory drug (NSAID), used to treat acute and chronic painful conditions. Fenbufen at both doses (800 mg or 400 mg, oral) had apparent analgesic efficacy^[3]. Fenbufen is a phenylalkanoic acid derivative with analgesic and anti-inflammatory activity. At a daily dosage of 600 mg, fenbufen is comparable with aspirin 3.6 g or indomethacin 75 mg in osteoarthritis^[4]. Like clinically used nonsteroidal anti-inflammatory drugs, Fenbufen shows activity in a wide spectrum of laboratory tests in mice, rats, guinea pigs, and dogs. Fenbufen has a long duration of anti-inflammatory and analgesic activity. Mechanistic studies indicate that fenbufen has no intrinsic effect on cyclooxygenase activity, whereas its major metabolite, biphenylacetic acid, is a potent inhibitor of prostaglandin synthesis. Comparative studies in the type II collagen arthritis model indicate that the anti-inflammatory properties of fenbufen are more potent than those of a second nonsteroidal anti-inflammatory drug, sulindac^[5].

Fenbufen 参考文献

[1]Syed M, Skonberg C, et al. Inhibition of ATP synthesis by fenbufen and its conjugated metabolites in rat liver mitochondria. Toxicol In Vitro. 2016 Mar;31:23-9.

[2]Naora K, Katagiri Y, et al. Effect of fenbufen on the pharmacokinetics of sparfloxacin in rats. J Antimicrob Chemother. 1992 Nov;30(5):673-83.

[3]Moore RA, Derry S, McQuay HJ. Single dose oral fenbufen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;2009(4):CD007547

[4]Brogden RN, Heel RC, Speight TM, Avery GS. Fenbufen: a review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain. Drugs. 1981 Jan;21(1):1-22

[5]Kerwar SS. Pharmacologic properties of fenbufen. Am J Med. 1983 Oct 31;75(4B):62-9

Fenbufen 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.66mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL

Fenbufen 技术信息

CAS号	36330-85-5
分子式	C₁₆H₁₄O₃
分子量	254.28
SMILES Code	O=C(O)CCC(C1=CC=C(C2=CC=CC=C2)C=C1)=O
MDL No.	MFCD00056701

别名	3-(4-联苯羰基)丙酸 ;CL-82204; Lederfen; Cinopal
运输	蓝冰
InChI Key	ZPAKPRAICRBAOD-UHFFFAOYSA-N
Pubchem ID	3335

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解方案

细胞实验：

DMSO: 50 mg/mL(196.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

Fenbufen {[allProObj[0].p_purity_real_show]}

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Fenbufen {[allProObj[0].p_purity_real_show]}

Fenbufen 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Fenbufen 质控信息

Fenbufen 生物活性

Fenbufen 参考文献

Fenbufen 实验方案

Fenbufen 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Fenbufen 纯度/质量文件产品仅供科研