Triptolide | PG490;NSC 163062;Tripterygium wilfordii | Apoptosis Inducer | Plant Standard | Anti-inflammation | Dopamine Receptor | Apoptosis | NF-κB | Tripterygium | Terpenes

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雷公藤甲素 /Triptolide {[allProObj[0].p_purity_real_show]}

货号：A550309 同义名： PG490;NSC 163062

Triptolide, a diterpene triepoxide extracted from the Chinese herb Tripterygium wilfordii, functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein.

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Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Triptolide 化学结构
CAS号：38748-32-2

Triptolide 3D分子结构
CAS号：38748-32-2

规格	价格	会员价	库存	数量
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Triptolide 纯度/质量文件产品仅供科研

货号：A550309 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell Host Microbe, 2024. Ambeed. [ A163338 ]; • Cancer Res., 2024. Ambeed. [ A295334 ]; • J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]; • J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]; • JBC, 2024, 107935. Ambeed. [ A194396 ]; 更多 >

多巴胺受体亚型比较
NF-κB 亚型比较

产品名称	D1 receptor ↓ ↑	D2 receptor ↓ ↑	D3 receptor ↓ ↑	D4 receptor ↓ ↑	D5 receptor ↓ ↑	DAT ↓ ↑	Dopamine receptor ↓ ↑	其他靶点	纯度
Penfluridol	+ Dopamine receptor, Ki: 1.6 μM								98%
Ansofaxine HCl	++ Dopamine receptor, IC50: 491 nM								98%
Tetrahydroberberine,THB		+ D2 receptor, pKi: 6.08							98+%
Prochlorperazine Maleate		✔							95%
Olanzapine		✔							99+%
Trifluoperazine		++++ Dopamine D2 receptor, IC50: 1.1 nM							98%
Ropinirole hydrochloride		++ D2 receptor, Ki: 29 nM							99%
Lurasidone		++++ D2 receptor, Ki: 1 nM							98%
Levosulpiride		✔							99+%
Pridopidine		✔							95%
Metoclopramide		✔					✔		99+%
Molindone HCl		✔							98%
Sulpiride		✔							99+%
Perospirone		++++ D2 receptor, Ki: 1.4 nM							99%
Perospirone HCl		++++ D2 receptor, Ki: 1.4 nM							98+%
Phenothiazine		✔							98%
Pimozide	+ Dopamine D1 receptor, Ki: 6600 nM	+++ Dopamine D2 receptor, Ki: 3.0 nM	++++ Dopamine D3 receptor, Ki: 0.83 nM						98%
Rotundine	++ D1 receptor, IC50: 166 nM	+ D2 receptor, IC50: 1.47 μM	+ D3 receptor, IC50: 3.25 μM						98%
Domperidone		✔							99+%
ONC206		✔							97%
Pimethixene maleate	++ Dopamine D1 Receptor, pKi: 6.37	+++ Dopamine D2 Receptor, pKi: 8.19		++ Dopamine D4.4 Receptor, pKi: 7.54					97%
Loxapine succinate	++ D2 receptor (Human), Ki: 62 nM D1 receptor (human), Ki: 26 nM	++ D2 receptor (human), Ki: 24 nM D2 receptor (bovine), Ki: 26 nM		+++ D4 receptor (human), Ki: 7.5 nM					99%
Chlorprothixene	+++ D1 receptor, Ki: 18 nM	+++ D2 receptor, Ki: 2.96 nM	+++ D3 receptor, Ki: 4.56 nM		+++ D5 receptor, Ki: 9 nM				98%
SCH-23390 HCl	++++ D1 dopamine receptor, Ki: 0.2 nM				++++ D5 dopamine receptor, Ki: 0.3 nM				98%
MPP+ iodide						✔			97%
σ1 Receptor antagonist-1						+ DAT, pKi: 5.8			97%
Benztropine mesylate						++ DAT, IC50: 118 nM			98%
Azaperone							✔		98%
Ziprasidone HCl							✔		98+%
Paliperidone							✔		98%
Alizapride HCl							✔		99+%
Amisulpride							✔		98%
Quetiapine hemifumarate							✔	Adrenergic Receptor	98%
Clozapine N-oxide							✔		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	NF-κB ↓ ↑	其他靶点	纯度
PDTC ammonium	✔		98%
QNZ	++++ NF-κB, IC50: 11 nM		99%+
Sodium 4-Aminosalicylate Dihydrate	✔		98%
Sodium Salicylate	✔		95%
Parthenolide	✔	p53	97% HPLC
JSH-23	+ NF-κB, IC50: 7.1 μM		98%
Phenethyl caffeate	✔		98%
Andrographolide	✔		98+%
Curcumin	✔	HDAC,Nrf2	98%
SC75741	+++ NF-κB, EC50: 200 nM		99%+
CBL0137 HCl	++ NF-κB, EC50: 0.47 μM	p53	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Triptolide 生物活性

描述

Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory and antiproliferative effects. Triptolide induces apoptosis in cultured and primary Chronic Lymphocytic Leukemia (CLL) B-cells. Treatment of CD19+ B cells with Triptolide, induces a dose-dependent increase in apoptosis in cultured and primary CLL cells. Consistent with the inhibition of heat-shock induced HSP transcription, treatment with Triptolide attenuates heat-shock induced expression of HSPs^[3]. Triptolide induced apoptosis in a subgroup of acute lymphoblastic leukemia (ALL) cells overexpressing the MDM2 oncoprotein by inhibiting MDM2 expression^[4]. Triptolide could protect differentiated PC12 cells against Aβ25-35-induced cytotoxicity and attenuate Aβ25-35-induced differentiated PC12 cell apoptosis. Triptolide could also suppress the level of autophagy^[5].

Triptolide 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
A549 cells		Cytotoxic assay		Cytotoxicity against human A549 cells, IC50=0.019 μM	21470864
human 786-O cells		Cytotoxic assay	72 h	Cytotoxicity against human 786-O cells after 72 hrs by MTT assay, IC50=0.022 μM	19637874
human A549 cells		Function assay		Antagonist activity at human PAR2 expressed in human A549 cells assessed as inhibition of 2f-LIGRLO-NH2-induced NFkappaB activation by luciferase reporter gene assay, IC50=0.014 μM	23895492
human A549 cells		Cytotoxic assay	72 h	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.059 μM	19637874

Triptolide 参考文献

[1]Yang S, Chen J, et al. Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther. 2003 Jan;2(1):65-72.

[2]Qiu D, Zhao G, et al. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem. 1999 May 7;274(19):13443-50.

[3]Ganguly S, Home T, Yacoub A, et al. Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia. Oncotarget.2015;6(31):31767-31779

[4]Huang M, Zhang H, Liu T, Tian D, Gu L, Zhou M. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Mol Cancer Ther. 2013;12(2):184-194

[5]Xu P, Li Z, Wang H, Zhang X, Yang Z. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta₂₅₋₃₅ via the Autophagy Pathway. PLoS One. 2015;10(11):e0142719.

Triptolide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.87mL

2.77mL

1.39mL

27.75mL

5.55mL

2.77mL

Triptolide 技术信息

CAS号	38748-32-2
分子式	C₂₀H₂₄O₆
分子量	360.401

别名	PG490;NSC 163062;Tripterygium wilfordii
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 25 mg/mL(69.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

2% DMSO+30% PEG 300+2% Tween 80+water 3 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

A549 cells	Cytotoxic assay		Cytotoxicity against human A549 cells, IC50=0.019 μM	21470864
human 786-O cells	Cytotoxic assay	72 h	Cytotoxicity against human 786-O cells after 72 hrs by MTT assay, IC50=0.022 μM	19637874
human A549 cells	Function assay		Antagonist activity at human PAR2 expressed in human A549 cells assessed as inhibition of 2f-LIGRLO-NH2-induced NFkappaB activation by luciferase reporter gene assay, IC50=0.014 μM	23895492
human A549 cells	Cytotoxic assay	72 h	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.059 μM	19637874
human Bel7402 cells	Cytotoxic assay	72 h	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay, IC50=0.02 μM	19637874
human DU145 cells	Cytotoxic assay	72 h	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50=0.024 μM	19637874
human HCT116 cells	Cytotoxic assay	72 h	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50=0.01 μM	19637874
human HCT15 cells	Cytotoxic assay	72 h	Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay, IC50=0.029 μM	19637874
human HeLa cells	Cytotoxic assay	72 h	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=0.047 μM	19637874
human HO8910 cells	Cytotoxic assay	72 h	Cytotoxicity against human HO8910 cells after 72 hrs by MTT assay, IC50=0.028 μM	19637874
human HT-29 cells	Cytotoxic assay		Cytotoxicity against human HT-29 cells, IC50=2.1 nM	21470864
human K562 cells	Cytotoxic assay	72 h	Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50=0.05 μM	19637874
human KB cells	Cytotoxic assay	72 h	Cytotoxicity against human KB cells after 72 hrs by MTT assay， IC50=0.043 μM	19637874
human KBM5 cells	Cytotoxic assay	72 h	Cytotoxicity against imatinib-resistant human KBM5 cells harboring Bcr-Abl T315I mutant after 72 hrs by MTS assay, IC50=0.0083 μM	20149665
human MCF7 cells	Cytotoxic assay	72 h	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.019 μM	19637874
human MDA-MB-231 cells	Cytotoxic assay	72 h	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50=0.024 μM	19637874
human MKN28 cells	Cytotoxic assay	72 h	Cytotoxicity against human MKN28 cells after 72 hrs by MTT assay, IC50=0.2 μM	19637874
human MOLT4 cells	Cytotoxic assay	72 h	Cytotoxicity against human MOLT4 cells after 72 hrs by MTT assay, IC50=0.017 μM	19637874
human PC3 cells	Proliferation assay	72 h	Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay, IC50=0.02 μM	20833543
human Rh30 cells	Cytotoxic assay	72 h	Cytotoxicity against human Rh30 cells after 72 hrs by MTT assay, IC50=0.014 μM	19637874
human SGC7901 cells	Cytotoxic assay	72 h	Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay， IC50=0.015 μM	19637874
human SKOV3 cells	Cytotoxic assay	72 h	Cytotoxicity against human SKOV3 cells after 72 hrs by sulforhodamine B assay, IC50=0.006 μM	24378709
human SMMC7721 cells	Cytotoxic assay	72 h	Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay, IC50=0.018 μM	19637874
human SW1116 cells	Cytotoxic assay	72 h	Cytotoxicity against human SW1116 cells after 72 hrs by MTT assay, IC50=0.052 μM	19637874
human U251 cells	Cytotoxic assay		Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay, IC50=0.033 μM	25467158
MDA-MB-468 cells	Cytotoxic assay		Cytotoxicity against human MDA-MB-468 cells by SRB assay, IC50=0.01 μM	19637874
MEF	Cytotoxic assay	72 h	Cytotoxicity against MEF after 72 hrs by MTS assay, IC5=9.2 μM	20149665
mouse 32D cells	Cytotoxic assay	72 h	Cytotoxicity against mouse 32D cells harboring wild type Bcr-Abl after 72 hrs by MTS assay, IC50=0.032 μM	20149665

雷公藤甲素 /Triptolide {[allProObj[0].p_purity_real_show]}

Triptolide 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Triptolide 质控信息

Triptolide 生物活性

Triptolide 细胞研究

Triptolide 参考文献

Triptolide 实验方案

Triptolide 技术信息

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雷公藤甲素 /Triptolide {[allProObj[0].p_purity_real_show]}

Triptolide 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Triptolide 质控信息

Triptolide 生物活性

Triptolide 细胞研究

Triptolide 参考文献

Triptolide 实验方案

Triptolide 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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